围手术期应用抗生素降低医院感染效果的前瞻性研究

笔者研究了１９９２年７月至１９９３年６月期间住院的５２５名颅内肿瘤病人，采用前瞻性研究的方法，将病人随机分为实验组和对照组，其中实验组１７５人围手术期应用抗生素，发生医院感染１１人（６．２９％），对照组３５０人术后常规预防性应用抗生素，发生医院感染６１人（１７．４３％），二者有显著性差别。在感染部位发病率方面，颅内感染发病率最高，其中实验组的颅内感染发病率为２．２９％，对照组颅内感染发病率为８．００％，二者也有显著差别。另外，调查也提示围手术期应用抗生素降低了病人住院时间、住院期间应用抗生素的费用和使用抗生素的时间。

A Prospective Study of Perioperative Antibiotic Prophylaxis in Reducing the rate of Nosocomial Infection Among Patients with Intracranial Tumors

his paper analysed 525 intracranial neoplastic patients who were hospitalized from July,1992to June,1993.The patients were randomly divided into control and experiment groups. In the ex-periment group,patients who received one kind of antibiotic during perioperation had a nosocomialinfection rate of 6.29%(11/175),while the patients in the control group where antibiotics wereroutinely used as usual had a rate of 17. 43%(61/350).There was a significant difference betweenthe control(8.00%)and experiment group(2.29%)in terms of the intracranial infection incidence.Perioperative antibiotic prophylaxis showed great influence on the expenditure of antibiotics andduration of hospitalization in the patients with intracranial neoplastic tumors.