| 磁性靶向紫杉醇微球制备的初步研究 |
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| 引用本文： | 林本兰,沈晓冬,崔升,施瑞华,凌亭生. 磁性靶向紫杉醇微球制备的初步研究[J]. 中国新药杂志, 2006, 15(13): 1081-1083 |
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| 作者姓名： | 林本兰 沈晓冬 崔升 施瑞华 凌亭生 |
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| 作者单位： | 1. 南京工业大学材料科学与工程学院,南京,210009
2. 南京医科大学第一附属医院,南京,210029 |
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| 基金项目： | 江苏省研究生培养创新工程项目;江苏省人民医院合作项目;解放军总装备部预研项目 |
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| 摘 要： | 目的：制备磁性靶向紫杉醇微球.方法：以紫杉醇和纳米Fe3O4为材料制备出磁性靶向紫杉醇微球,并利用高分辨透射电子显微镜（HRTEM）观察微球的形貌,同时采用紫外可见分光光度法测定微球的载药量和包封率.结果：磁性靶向紫杉醇微球的载药量为3.013%,包封率为35.26%.结论：通过实验研究制备了磁性紫杉醇微球,具有靶向定位功能,形成一种磁靶向给药系统.
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| 关 键 词： | 紫杉醇 磁靶向给药系统 紫外可见分光光度法 载药量 |
| 文章编号： | 1003-3734（2006）13-1081-03 |
| 修稿时间： | 2005-11-15 |
Preparation of magnetic targeted paclitaxel-loaded microspheres |
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| LIN Ben-lan,SHEN Xiao-dong,CUI Sheng,SHI Rui-hua,LING Ting-sheng. Preparation of magnetic targeted paclitaxel-loaded microspheres[J]. Chinese Journal of New Drugs, 2006, 15(13): 1081-1083 |
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| Authors: | LIN Ben-lan SHEN Xiao-dong CUI Sheng SHI Rui-hua LING Ting-sheng |
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| Affiliation: | 1. College of Material Science and Technology, Nanjing Industrial University, Nanjing 210009, China; 2. The First Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China |
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| Abstract: | Objective:To prepare magnetic targeted paclitaxel-loaded microspheres.Methods: The magnetic targeted paclitaxel-loaded microspheres were prepared using magnetic Fe_3O_4 nanopartieles. The morphology of microspheres was observed by using high resolution transmit electron micrograph(HR- TEM).The drug-loading rate and encapsulation rate of the microspheres were measured by ultraviolet and visible spectrophotometry.Results:The microspheres showed a drug-loading rate of 3.013% and the encapsulation rate of 35.26%.Conclusion:The magnetic paclitaxel-loaded microspheres formed a mag- netic targeted drugs delivery system. |
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| Keywords: | paclitaxel magnetic targeted drugs delivery system UV spectrophotometry drugloading rate |
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