鼻咽癌调强放疗中靶区及危及器官的体积和剂量变化

目前调强放疗是鼻咽癌的主要治疗手段.在6～7周的疗程中,临床大部分医师均使用初始制定的放疗计划.研究表明,由于原发肿瘤和转移淋巴结的缩小以及体质量下降导致的正常组织和体表轮廓的收缩,这些有意义的变化将影响靶区及危及器官的剂量分布,从而影响部分患者的治疗疗效.鼻咽癌调强放疗期间复位并进行靶区修改很有必要.

Changes of volume and dose in target volume and organ at risk for nasopharyngeal carcinoma during intensity modulated radiotherapy

At present,intensity modulated radiation therapy has been the main treatment of nasopharyngeal carcinoma.In the course of 6-7 weeks,most physicians use the initial formulation of the radiotherapy plan.Studies have indicated that the reduction of primary tumor and lymph nodes,as well as the reduction of normal tissue and body surface profile due to the weight loss,will affect the dose distribution of the target and the organs at risk,so as to influence the therapeutic effect of some patients.Therefore,it is necessary to reset and modify the target volumes during the radiotherapy for nasopharyngeal carcinoma.