自噬及其与干性年龄相关性黄斑变性发病的相关性

年龄相关性黄斑变性(age-related macular degeneration,AMD)是老年人首要致盲眼病,发病率呈不断上升趋势.而干性AMD占85％ ～ 90％,其病因尚未完全阐明.自噬是指细胞中需要降解的蛋白质和细胞器等成分被包裹,并最终运送到溶酶体降解的过程,是清除细胞内受损蛋白及细胞器的主要途径,对维持细胞内环境稳态至关重要.多项研究显示自噬失调与AMD目前所知的主要发病机制,即氧化应激、炎症及视网膜色素上皮细胞代谢障碍密切相关,为从自噬方面探索AMD治疗方案提供一些思路和方向.

Autophagy and its relationship with atrophic age-related macular degeneration

Age-related macular degeneration is the main cause of blindness of elderly patients and its prevalence has been increasing worldwide.Despite close attention was paid on AMD,its pathogenesis is still not fully understood and the research has been regarded as an essential project in vision science.Autophagy refers to the process which targeted proteins and organelles were packaged and transported for degradation in lysosome,which is a major catabolic pathway involved in maintaining intracellular homeostasis.Mutiple researches suggested that autophagy also has a close relationship with AMD-related pathogenesis such as oxidative stress,inflammation and retinal pigment epithelium disorders,which may present some ideas of autophagic treatment for AMD.