Two flavonol glycosides from Liparis bootanensis |
| |
| Authors: | Shuai Huang Run Wu Feng Gao Chunying Li Xianli Zhou |
| |
| Affiliation: | 1.Chemistry and Biodiversity Laboratory of the School of Life Science and Engineering,Southwest Jiaotong University,Chengdu,People’s Republic of China;2.Center for Molecular and Translational Medicine, Institute of Biomedical Sciences,Georgia State University,Atlanta,USA |
| |
| Abstract: | ![]()
Two new flavonol glycosides, bootanenside I and II (1 and 2), along with ten known compounds (3–12), were isolated from whole plant of Liparis bootanensis Griff. Their structures were elucidated on the basis of extensive spectroscopic analyses, including high-resolution electrospray-ionization mass spectrometry (HR–ESIMS) and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR). The cytotoxicity of the compounds was investigated against HCT116 human cancer cell line, revealing that none of them possessed considerable cytotoxic activity. Bioassays of the new metabolites showed that compounds 1 and 2 displayed moderate in vitro antiinflammatory activity by inhibiting expression of inducible nitric oxide synthase (iNOS) protein in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
