噻吗洛尔眼液治疗LASIK术后屈光回退54例疗效分析

目的:分析总结2.5g/L马来酸噻吗洛尔眼液(timolol)对准分子激光原位角膜磨镶术(laserin situkeratomileusis,LASIK)后屈光回退的治疗效果。方法:选取我院准分子中心2007-08/2008-08接受LASIK手术病例1400例2650眼,随访0.5a以上,发生屈光回退者有53例66眼,按手术时间随机分为两组,试验组使用2.5g/L马来酸噻吗洛尔眼液进行治疗,对照组使用1g/L玻璃酸钠眼液进行治疗,两组治疗时间均为2wk,治疗结束后将试验组与对照组进行分析比较(视力提高行数)。结果:试验组视力提高-1~4(平均1.45±1.09)行,对照组视力提高-2~2(平均0.61±0.86)行,行成组t检验显示,两组差异有统计学意义(t=3.500,P<0.05)。结论:马来酸噻吗洛尔眼液2.5g/L对LASIK术后屈光回退具有显著疗效。

Clinical analysis of timolol eye drops treatment on 54 cases of refractive regression after LASIK

·AIM:To analyze and sum up therapeutic effect of 2.5g/L timolol maleate eye drops on the refractive regression after excimer laser in situ keratomileusis(LASIK).·METHODS:Fifty-three cases(66 eyes)with refractive regres-sion from 1 400 cases(2 650 eyes)of excimer LASIK surgery in our hospital centers 2007-08/2008-08 after follow-up of more than 0.5 year were randomly divided into two groups according to operation time.The test group was treated with 2.5g/L timolol maleate eye drops.The control group was treated with 1g/L sodium hyaluronate eye drops.Treatment time of both groups was 2 weeks.At the end of treatment,the test group and the control group were analyzed comparatively(visual acuity increased by the number of lines).·RESULTS:The test group visual acuity was improved-1-4 lines(average 1.45±1.09 lines),the control group visual acuity was improved-2-2 lines(average 0.61±0.86 lines),Group t tests showed differences between the two groups was statistically significant(t=3.500,P<0.05).·CONCLUSION:Timolol maleate eye drops 2.5g/L have significant effect on postoperative refractive regression after LASIK.·