心肌细胞损伤模型构建及应用的研究进展

心肌细胞损伤模型目前被广泛应用于心血管疾病的分子机制及药物作用的研究，因各种模型的形成机制不同，选择合适的模型非常重要。临床心血管疾病的病理变化相对复杂，根据其特点采用的心肌细胞损伤模型主要有过氧化氢心肌细胞损伤模型、缺氧/复氧心肌细胞损伤模型、阿霉素心肌细胞损伤模型、高糖/高脂心肌细胞损伤模型、异丙肾上腺素心肌细胞损伤模型等。几种模型均有优缺点，需要根据研究内容选择相对合适的心肌细胞损伤模型。

Research progress in building and applyingcardiomyocytes injury model

Cardiomyocytes injury model has been widely used in the study for the molecularmechanism of cardiovascular diseases and drug action. It is very important to select theappropriate model due to the different formation mechanisms for various models. Clinicalcardiovascular pathological change is relatively complex. Currently used models accordingto the characteristics of clinical cardiovascular diseases mainly include hydrogen peroxideinducedmyocardial cell damage model, hypoxia reoxygenation injury model, adriamycininducedmyocardial cell damage model, high sugar high fat-induced myocardial celldamage model, and isoprenaline-induced myocardial cell damage model. Every model hasits advantages as well as its disadvantages. The suitable model of myocardial cell injurycan be selected according to the research purpose.