人芽囊原虫感染动物模型构建研究进展

人芽囊原虫是一种常见的寄生于人和动物肠道内的寄生原虫，其致病性尚有争议。构建动物模型对于研究人芽囊原虫致病性、致病机制以及药物筛选等具有重要意义。实验动物、感染方式和虫体选择以及宿主免疫状态是影响人芽囊原虫感染动物模型构建的重要因素。本文综述了近年来人芽囊原虫感染动物模型的相关研究进展，阐述了构建人芽囊原虫感染动物模型的影响因素及其应用，旨在为动物感染模型选择提供借鉴。

Progress of research on animal models of Blastocystis hominis infections

Blastocystis hominis is a common parasitic protozoa in human and animal intestines;however,its pathogenicity remains controversial.Construction of animal models is of great significance to investigate the pathogenicity,pathogenic mechanisms and drug screening of B.hominis.Experimental animals,mode of infections,parasite strains and host immune status are important factors affecting the successful modeling of B.hominis infections in animals.Hereby,we review the progress of researches on animal models of B.hominis infections,and summarize the influencing factors and application of animal models of B.hominis infections,in order to provides insights into the selection of animals models of B.hominis infections.