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Procyanidins inhibit tumor angiogenesis by crosslinking extracellular matrix |
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| Authors: | Wan-yin Zhai Chun-ping Jia Hui Zhao Yuan-sen Xu |
| Affiliation: | Wan-yin Zhai1,2,3,Chun-ping Jia1,Hui Zhao1,Yuan-sen Xu1* 1State Key Lab of Transducer Technology,Shanghai Institute of Microsystem and Information Technology,Chinese Academy of Sciences,Shanghai,200068,China,2Graduation School,Beijing,3Biomaterials and Tissue Engineering Research Center,Shanghai Institute of Ceramics |
| Abstract: | Objective: Procyanidins (PC) are widely available natural polyphenols. The present study is designed to investigate if PC can inhibit angiogenesis in lung adenocarcinoma xenografts through crosslinking vascular extracellular matrix (ECM) and preventing proteolysis by matrix metalloproteinases (MMPs). Methods: Using the in vitro MMP-2 proteolysis and in vivo subcutaneous implantation models, we investigated if PC crosslinking inhibits MMP-mediated proteolysis. Using a cultured cell detachment assay, an in vi... |
| Keywords: | Procyanidins Crosslinking Extracellular matrix Matrix metalloproteinases Angiogenesis |
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