丁型肝炎病毒和乙型肝炎病毒感染关系的探讨

STUDY ON THE RELATIONSHIP OF HDV AND HBV INFECTION

HDV was demonstrated in the hepatocytes of 39 samples (13.8%) out of 263 liver tissue sections biopsied from AH,CPH,LC and PHG patients by immuno-histological stain.HDV was not found in 19 samples with negative HBVM and 1 sample in which HBVM was not tested.So,all 39 sampled (14.8%) with positive HDV belonged to the 263 patients with positive HBVM.Among the 199 cases with positive HBsAg in blood,HDV was found in liver tissue of 36 patients (18.1%),but in 64 cases with negative HBsAg,HDV was demonstrated only in that of 3 patents (4.7%)..The distribution of HDV infection was not even in China according to the published literature.This perhaps was related to the sample size of investigation and,especially,the clinical diagnosis of the HBV infection of the investigated patients.Our investigation has proved that the detectable rate of HDV infection in chronic HBV infection was significantly higher than in acute infection,indicating that HDV infection might be a cause of chronicitization of HBV infection.The fact that HDV was accompanied with HBsAg and/or HBcAg in 87.2% liver tissue sections,suggested there was a relationship between HDV and HBV infection.