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The long-term effects of metoprolol and epanolol on tissue-type plasminogen activator and plasminogen activator inhibitor 1 in patients with ischaemic heart disease |
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| Authors: | R. A. Wright A. M. Perrie F. Stenhouse K. G. M. M. Alberti R. A. Riemersma I. R. MacGregor N. A. Boon |
| Affiliation: | (1) Cardiovascular Research Unit, University of Edinburgh, Edinburgh, UK;(2) Scottish National Blood Transfusion Service, Headquarters Laboratory, Edinburgh, UK;(3) Department of Medicine, University of Newcastle Upon Tyne, Newcastle upon Tyne, UK;(4) Department of Cardiology, Royal Infirmary, Lauriston Place, EH3 9YW Edinburgh, UK |
| Abstract: | This double-blind, randomized parallel group study investigated the effect of 6 months  -adrenoceptor antagonist therapy with either metoprolol (1-selective without intrinsic sympathomimetic activity [ISA]) or epanolol (1-selective with ISA) on markers of endogenous fibrinolysis in 20 patients with chronic stable angina receiving concurrent treatment with nifedipine.Neither drug had an effect on tissue-type plasminogen activator or plasminogen activator inhibitor type 1 (PAI-1). A significant correlation between fasting insulin and PAI-1 has previously been described and was confirmed in this study. The group treated with metoprolol showed a significant rise in fasting insulin after 6 months with no change in PAI-1.This suggests that the previously described link between these two may not be causal. |
| Keywords: | Metoprolol Epanolol Ischaemic heart disease tissue-type plasminogen activator plasminogen activator inhibitor type 1 |
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