| 健脾活血方对激素性股骨头坏死血管内皮生长因子表达的影响 |
| |
| 引用本文： | 田 能,孔祥英,万 蓉,林 娜,李 莉,陈卫衡.健脾活血方对激素性股骨头坏死血管内皮生长因子表达的影响[J].中国实验方剂学杂志,2010,16(2):48-51. |
| |
| 作者姓名： | 田 能 孔祥英 万 蓉 林 娜 李 莉 陈卫衡 |
| |
| 作者单位： | 1. 中国中医科学院中药研究所,北京,100700
2. 中国中医科学院骨伤科研究所,北京,100700 |
| |
| 基金项目： | 国家自然科学基金面上资助项目(30472131,30873394) |
| |
| 摘 要： | 目的:通过观察健脾活血方对激素性股骨头坏死(SONFH)鸡股骨头内血管内皮生长因子(VEGF)表达的影响,探讨其防治SONFH的作用机制。方法:胸肌注射甲基氢化泼尼松建立SONFH模型,64只来航鸡随机平均分为正常组、模型组、洛伐他汀组和健脾活血组;实验8周和16周翼下静脉采血测定血清总胆固醇(CHO)和甘油三酯(TG)的含量,并取双侧股骨头行HE染色观察其组织病理学改变,用免疫组织化学法检测股骨头内VEGF的表达水平。结果:实验8周和16周,模型组股骨头出现空骨陷窝率和脂肪面积明显增多等病理改变,与正常组相比,股骨头内VEGF表达明显减少(P0.05),血清CHO、TG水平明显升高;洛伐他汀与健脾活血方能不同程度改善由激素引起的股骨头坏死组织形态学改变,升高股骨头内VEGF的表达,减低血清TG、CHO水平(与模型组比较P0.05)。结论:健脾活血方可上调股骨头内VEGF的表达,这可能是其有效改善股骨头微循环障碍,防治SONFH的作用机制之一。
|
| 关 键 词： | 激素性股骨头坏死 健脾活血 总胆固醇 甘油三酯 血管内皮生长因子 |
| 收稿时间： | 2009/6/26 0:00:00 |
Effect of Jianpi Huoxue Decoction on the Expression of Vascular Endothelial Growth Factor in Steroid-induced Osteonecrosis of the Femoral Head |
| |
| TIAN Neng,KONG Xiang-ying,WAN Rong,LIN N,LI Li and CHEN Wei-heng.Effect of Jianpi Huoxue Decoction on the Expression of Vascular Endothelial Growth Factor in Steroid-induced Osteonecrosis of the Femoral Head[J].China Journal of Experimental Traditional Medical Formulae,2010,16(2):48-51. |
| |
| Authors: | TIAN Neng KONG Xiang-ying WAN Rong LIN N LI Li and CHEN Wei-heng |
| |
| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences,Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences,Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences,Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences,Beijing 100700, China;Institute of Orthopaedics and Traumatology,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Orthopaedics and Traumatology,China Academy of Chinese Medical Sciences,Beijing 100700,China |
| |
| Abstract: | Objective:To investigate the effect of Jianpi Huoxue Decoction on the expression of vascular endothelial growth factor(VEGF) in the femoral head of chicken with Steroid-induced Osteonecrosis of the Femoral Head(SONFH),as well as to explore the mechanism of prevention and treatment for SONFH.Methods:The animal model of SONFH was established with injection of methylprednisolone in chest muscle of chickens.64 Leghorn chickens were randomly divided into normal control group,model group,lovastatin group and Jian... |
| |
| Keywords: | steroil-induced osteonecrosis of the femoral head Jianpi Huoxue CHO TG VEGF |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 |
| 点击此处可从《中国实验方剂学杂志》下载免费的PDF全文 |
|
