蒜珠对小鼠移植性肝癌的疗效研究

目的 探讨蒜珠对小鼠移植性肝癌Hsc-2治疗效果及对小鼠免疫功能的影响。方法 昆明小鼠接种肝癌Hsc-2细胞株，口服蒜珠匀浆10d后，处死动物，剥离瘤块，称取瘤重；分离脾、胸腺并称重。ConA诱导小鼠T淋巴细胞增殖反应的影响。结果 与对照组相比，蒜珠匀浆剂量在0．6ml／20g体重和0．4ml／20g体重口服给药情况下，瘤灶稳定或缩小，肿瘤抑制率分别为46．34％、30．49％；ConA的OD值与生理盐水组相比均有显著性差异。结论 蒜珠抗肿瘤作用明显，能增强小鼠机体的免疫功能。

Antitumor Effects of Garlic on Transplanted Liver Carcinoma in Mice

Objective To explore the antitumor effects of garlic on marine transplanted liver carcinoma and to investigate the changes of immune function in the model of marine-transplanted carcinoma.Methods the KM mice were given garlic plasma orally after hepatocyte cell line Hsc-2 was vacciated to the mice and developed into transplanted liver carcinoma.Ten days later, the animals were sacrificed and the tumors were stripped from the liver and weighed. The spleen and thymus were resected and weighed too. The ConA experiment was introduced to observe the T lymph cell proliferation.Results Compared with the control group the tumor sites in experimental group kept stable or were shrunk when garlic plasma were given orally at 0.6 ml/20g or 0.4 ml/20g. The tumor inhibitory rates were 46.3% and 30.4% respectivel. OD values in experimental group was significant difference from those of control group.Conclusion Antitumor effect of garlic on marine transplanted liver carcinoma was apparent. Garlic could improve immune function in mice.