Diffusion-Weighted Imaging for Pretreatment Evaluation and Prediction of Treatment Effect in Patients Undergoing CT-Guided Injection for Lumbar Disc Herniation |
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| Authors: | Xiang-Ke Niu Anup Bhetuwal Han-Feng Yang |
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| Affiliation: | 1Department of Radiology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan Province 610000, China.;2Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province 637000, China. |
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| Abstract: | ObjectiveTo determine whether a change in apparent diffusion coefficient (ADC) value could predict early response to CT-guided Oxygen-Ozone (O2-O3) injection therapy in patients with unilateral mono-radiculopathy due to lumbar disc herniation.ResultsOswestry Disability Index and the ADC index was not significantly correlated (r = -0.125, p = 0.093). The ADC index and ODI recovery ratio was significantly correlated (r = 0.819, p < 0.001). When using 7.10 as the cut-off value, the ADC index obtained a sensitivity of 86.3% and a specificity of 82.9% for predicting successful response to therapy around the first month of follow-up.ConclusionThis preliminary study demonstrates that the patients with decreased ADC index tend to show poor improvement of clinical symptoms. The ADC index may be a useful indicator to predict early response to CT-guided O2-O3 injection therapy in patients with unilateral mono-radiculopathy due to lumbar disc herniation. |
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| Keywords: | CT-guided spinal injections Periradicular injection Diffusion weighted image Apparent diffusion coefficient Dorsal root ganglion |
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