新生儿窒息后血清心肌酶谱的变化及意义

目的观察心肌酶谱在窒息后新生儿缺氧性心肌损伤中的变化及其临床意义。方法选择窒息新生儿40例,按照窒息程度分为2组分别于生后24h内和生后第3d、第7d检测血清肌酸激酶(CK)、肌酸激酶心型同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH),并将同期住院的非缺氧新生儿20例,作为对照组进行比较分析。结果(1)轻度窒息组和重度窒息组患儿,出生后24h内及生后第3d的CK、CK-MB、LDH、α-HBDH均明显升高,与对照组有显著性意义(P<0.01);重度窒息组与轻度窒息组之间CK、CK-MB、LDH和α-HBDH亦有显著性意义(P均<0.01);(2)24小时内重度窒息组与轻度窒息组CK-MB升高最为明显;生后第3天,CK和LDH、α-HBDH逐渐达高峰;第7d轻度窒息组CK、CK。MB、α-HBDH呈下降趋势,逐渐降至正常水平,而LDH仍呈升高水平,与对照组比较有显著差异(P<0.05);结论(1)新生儿窒息早期即有心肌酶的改变,表现缺氧程度与心肌酶水平升高呈正相关;(2)缺氧性心肌损害与新生儿窒息程度有相关性;(3)心肌酶谱检测对进一步诊断新生儿窒息后心肌损害有重要价值;(4)新生...

The Clinical Significance of Myocardial Enzyne Detection in Asphyxia Newborn

Objective To observe the variety of myocardial enzyme with the anoxic myocardial injury and its clinical significance in asphyxia newborn.Methods and methods 40 asphyxia newborn hospitalized in neonatal intensive care unit(NICU),were classified into mild asphyxia group(20 cases)and severe asphyxia group(20 cases)by the degree of asphyxia.Creatine kinase(CK),creatine kinase and myocardial myogiobin isoenzyme(CK-MB),lactate dehydrogenase(LDH),a.hydro.oxybutryrate dehydrogenase(a-HBDH)were tested on the 24th h...