Severe varicella infection during treatment with infliximab for Crohn's disease |
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| Authors: | Tougeron David Mauillon Jacques Tranvouez Jean-Luc |
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| Affiliation: | 1. Faculty of Physics, University of Vienna, 1090 Vienna, Austria;2. Graduate School of Energy Science, Kyoto University, Kyoto 606-8501, Japan;3. Faculty of Sciences, University of Granada, 18071 Granada, Spain;4. Atmospheric Optic Group,University of Valladolid, Spain;1. Center for Space and Habitability, University of Bern, Siddlerstrasse 5, Bern 3012, Switzerland;2. Department of Physics, University of Oxford, Clarendon Laboratory, Parks Road, Oxford, UK;1. Department of Respiratory Medicine, Hospital Universitario de Getafe, Spain;2. Department of Internal Medicine, Hospital Universitario de Getafe, Spain;3. Department of Radiology, Hospital Universitario de Getafe, Spain;1. Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah;2. Department of Human Genetics, University of Utah, Salt Lake City, Utah;3. Division of Immunology and the Manton Center for Orphan Disease Research, Boston Children''s Hospital, Harvard Medical School, Boston, Mass;4. RUCDR, Rutgers University, Piscataway, NJ;5. Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md;6. Division of Hematology/Blood and Marrow Transplantation, University of Utah School of Medicine, Salt Lake City, Utah;7. Harvard Stem Cell Institute, Harvard Medical School, Boston, Mass;8. Pediatric Immunodeficiency Program, Division of Allergy, Massachusetts General Hospital for Children, Boston, Mass |
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| Abstract: | ![]()
Immunosupressive agents have improved the treatment of severe Crohn's disease. Infliximab is increasingly used in the treatment of Crohn's disease refractory to the usual treatment or with fistulas. However, there is a risk of infection and benign viral infections can became severe. We report the case of a patient treated by azathioprine and infliximab who developed serious chickenpox with multi visceral localisations and transfer to intensive care. There are a few cases of severe varicella infection in the literature with hepatitis and pneumonia in patients treated with infliximab. We review the clinical aspects, therapeutic strategy and prevention of chickenpox in immunodepressed patients. |
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