| 新疆紫草提取物脂质体制备工艺的初步筛选 |
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| 引用本文： | 李国英,买尔旦·马合木提,古丽仙·胡加. 新疆紫草提取物脂质体制备工艺的初步筛选[J]. 中国药房, 2010, 0(15): 1376-1378 |
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| 作者姓名： | 李国英 买尔旦·马合木提 古丽仙·胡加 |
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| 作者单位： | 新疆医科大学附属肿瘤医院;新疆医科大学药学院; |
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| 摘 要： | 目的:筛选新疆紫草提取物脂质体的制备工艺。方法:分别采用薄膜分散法、逆相蒸发法、乙醇注入法、乙醚注入法和熔融法制备新疆紫草提取物(AEE)脂质体,以包封率、形态、粒径分布等为指标比较5种方法的适用性。结果:薄膜分散法、逆相蒸发法、乙醇注入法与乙醚注入法制得的脂质体形态较完整,大小较均匀;其中乙醇注入法制备的AEE脂质体包封率最高,为(63.53±0.71)%。结论:乙醇注入法适合于AEE脂质体的制备。
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| 关 键 词： | 新疆紫草提取物 脂质体 制备工艺 包封率 |
Initial Selection of Preparation Technology of Liposome from Arnebia euehroma |
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| Affiliation: | LI Guo-ying, Maierdan. Mahemuti (Tumor Hospital of Xinjiang Medical University, Urumqi 830011, China) LI Guo-ying, Maierdan. Mahemuti, Gulixian-Hujia(College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China) |
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| Abstract: | OBJECTIVE:To select the preparation process of liposome of Arnebia euehroma. METHODS:Thin film dispersion method,reverse phase evaporation method,ethanol injection-extrude method,ether injection method and melting methods were used to prepare the liposome of A. euehroma,respectively. The applicability of these five methods was compare with encapsulation efficiency,shapes and the distribution of particles size as indexes. RESULTS:All the methods obtained the liposome in perfect shape and uniform size with th... |
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| Keywords: | Extracts of Arnebia euehroma Liposome Preparation technology Encapsulation efficiency |
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