| 体内高糖环境下肝脏卵圆细胞的功能研究 |
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| 引用本文： | 李影,赵丽娟,李艳香,夏芳珍,陆颖理. 体内高糖环境下肝脏卵圆细胞的功能研究[J]. 中华内分泌代谢杂志, 2011, 27(7). DOI: 10.3760/cma.j.issn.1000-6699.2011.07.017 |
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| 作者姓名： | 李影 赵丽娟 李艳香 夏芳珍 陆颖理 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院内分泌代谢科,200011 |
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| 基金项目： | 上海交通大学 医工(理)交叉研究重点基金项目 |
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| 摘 要： | 以链脲佐菌素(STZ)诱导肝脏卵圆细胞模型大鼠体内高血糖,检测肝脏中胰岛素和转录因子(PDX-1、Nkx6.1)mRNA的表达.可见体内高糖环境下,肝脏胰岛素染色阳性,Nkx6.1和Pdx1mRNA表达明显增强,并有胰岛素1 mRNA的表达.提示高糖环境下,肝脏卵圆细胞可分化为胰岛素分泌细胞.Abstract：Rat hepatic oval cell model was induced by hyperglycemia and streptozotocin in vivo. Expression of insulin and mRNA expression of pancreatic transcription factors(Nkx6.1, PDX-1) were carried out. It showed that under high glucose, liver tissues were positive for insulin staining, the expression of Nkx6.1 and Pdx-1mRNA was significantly enhanced, and insulin-1mRNA was found to be expressed. The result suggests that under high glucose, hepatic oval cells can differentiate into insulin-producing cells.
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| 关 键 词： | 高血糖 肝脏卵圆细胞 胰岛素分泌细胞 体内 |
The function of hepatic oval cells under high glucose condition in vivo |
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| LI Ying,ZHAO Li-juan,LI Yan-xiang,XIA Fang-zhen,LU Ying-li. The function of hepatic oval cells under high glucose condition in vivo[J]. Chinese Journal of Endocrinology and Metabolism, 2011, 27(7). DOI: 10.3760/cma.j.issn.1000-6699.2011.07.017 |
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| Authors: | LI Ying ZHAO Li-juan LI Yan-xiang XIA Fang-zhen LU Ying-li |
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| Abstract: | Rat hepatic oval cell model was induced by hyperglycemia and streptozotocin in vivo. Expression of insulin and mRNA expression of pancreatic transcription factors(Nkx6.1, PDX-1) were carried out. It showed that under high glucose, liver tissues were positive for insulin staining, the expression of Nkx6.1 and Pdx-1mRNA was significantly enhanced, and insulin-1mRNA was found to be expressed. The result suggests that under high glucose, hepatic oval cells can differentiate into insulin-producing cells. |
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| Keywords: | High glucose Hepatic oval cell Insulin-producing cell in vivo |
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