| 抑郁症患者局部脑功能静息态磁共振成像研究 |
| |
| 引用本文： | 王晓霞,蒋成刚,冯正直.抑郁症患者局部脑功能静息态磁共振成像研究[J].第三军医大学学报,2011,33(10):1052-1055. |
| |
| 作者姓名： | 王晓霞 蒋成刚 冯正直 |
| |
| 作者单位： | 王晓霞,冯正直,Wang Xiaoxia,Feng Zhengzhi(第三军医大学护理系心理教研室,重庆,400038);蒋成刚,Jiang Chenggang(第三军医大学大坪医院野战外科研究所神经内科,重庆,400042) |
| |
| 摘 要： | 目的通过静息态功能磁共振成像(rsfMRI)技术和局部一致性(regional homogeneity,ReHo)分析方法,探讨抑郁症患者基础状态下自发神经活动特点及脑功能变化。方法选取年龄、性别和文化程度匹配的10例抑郁症患者和13例正常对照组被试,采用DPARSF软件进行静息态功能数据的预处理,计算两组被试全脑的ReHo值。采用SPM5软件对两组全脑ReHo值进行基于体素的组间比较,考察抑郁症患者和正常对照组静息状态脑功能差异。结果与正常对照组相比,抑郁症患者存在涉及顶叶、颞叶和边缘叶等多个认知控制和情绪加工相关脑区的自发神经活动异常,其中右侧丘脑、左侧下顶叶、缘上回、右侧小脑、右侧顶内沟和右侧齿状回表现出功能一致性增强(P<0.01),中脑和右侧后扣带回功能一致性减弱(P<0.01)。结论抑郁症患者存在多个脑区的静息态功能一致性异常,这些区域多与认知控制和情绪加工有关。
|
| 关 键 词： | 局部一致性 静息态 抑郁症 功能磁共振成像 |
Regional brain functional connectivity of depressed patients with restingstate functional magnetic resonance imaging |
| |
| Wang Xiaoxia,Jiang Chenggang,Feng Zhengzhi.Regional brain functional connectivity of depressed patients with restingstate functional magnetic resonance imaging[J].Acta Academiae Medicinae Militaris Tertiae,2011,33(10):1052-1055. |
| |
| Authors: | Wang Xiaoxia Jiang Chenggang Feng Zhengzhi |
| |
| Institution: | Wang Xiaoxia1,Jiang Chenggang2,Feng Zhengzhi1(1Department of Psychology,School of Nursing,Third Military Medical Uniuersity,Chongqing,400038,2Department of Neurology,Institute of Surgey Research,Daping Hospital,Third Military Medical University,400042,China) |
| |
| Abstract: | Objective To examine spontaneous neuronal activity(SNA) and brain function alteration of major depression patients with resting-state functional magnetic resonance imaging(rsfMRI) and regional homogeneity(ReHo) analysis.Methods Ten major depression patients and thirteen healthy controls,matched for age,sex and education,were enrolled and scanned with rsfMRI.The rsfMRI data were preprocessed and calculated to obtain whole brain ReHo values with DPARSF software.The raw ReHo values were subjected to t-test of ... |
| |
| Keywords: | regional homogeneity resting state depression functional magnetic resonance imaging |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
