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| 自发性高血压大鼠颈动脉血管平滑肌中抑癌基因P53和原癌基因c-jun、c-fos、c-myc mRNA表达的研究 | |
| 引用本文： | 刘洪,向前,祝平菊,孙明,尹卫东,刘英山.自发性高血压大鼠颈动脉血管平滑肌中抑癌基因P53和原癌基因c-jun、c-fos、c-myc mRNA表达的研究[J].南华大学学报(医学版),2005,33(3):347-349. |
| 作者姓名： | 刘洪 向前 祝平菊 孙明 尹卫东 刘英山 |
| 作者单位： | 1. 深圳市南山医院,广东,深圳,518051 2. 中南大学,附属湘雅医院,湖南,长沙,410078 3. 南华大学,医学院,湖南,衡阳,421001 |
| 基金项目： | 深圳市科技局课题(批准号980013). |
| 摘 要： | 目的探讨自发性高血压大鼠颈动脉中抑癌基因P53和原癌基因c-jun、c-fos、c-myc mRNA的表达.方法用逆转录聚合酶链式反应检测两种基因的表达水平.正常雄性大鼠作为对照组.结果 SHR颈动脉中,抑癌基因P53和原癌基因c-jun、c-fos、c-myc均有高表达,较WKY差异有显著性(P<0.05).结论自发性高血压大鼠颈动脉组织中抑癌基因P53和原癌基因c-jun、c-fos、c-myc均有高表达,癌基因的活化可能与自发性高血压大鼠颈动脉血管重构有关. |
| 关 键 词： | 自发性高血压大鼠 抑癌基因 原癌基因 血管重构 |
| 文章编号： | 1672-7444(2005)03-0347-03 |
| 修稿时间： | 2005年4月18日 |
The Effect of ACEI on Expression of Tumor Suppressor Gene and Oncogenes in Carotid Smooth Muscle From the Spontaneous Hypertension Rats |
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| LIU Hong,XIANG Qian,ZHU Ping-ju,et al.The Effect of ACEI on Expression of Tumor Suppressor Gene and Oncogenes in Carotid Smooth Muscle From the Spontaneous Hypertension Rats[J].Journal of Nanhua University(Medical Edition),2005,33(3):347-349. | |
| Authors: | LIU Hong XIANG Qian ZHU Ping-ju |
| Abstract: | Objective To study the mRNA expression of tumor suppressor gene P53 and oncogene c-jun,c-fos,c-myc in carotid smooth muscle from the spontaneous hypertension rat (SHR). Methods The mRNA expression of these genes were examined by RT-PCR. WKY was experimented as control group. Results The mRNA of these genes expressed obviously in SHR, and had evident difference compared with WKY'(P<0.05). Conclusion In SHR carotid smooth muscle ,the expression of tumor suppressor gene P53 and oncogene c-jun,c-fos and c-myc expressed obviously. The expression probably related to carotid reconstruction. |
| Keywords: | spontaneous hypertension rat (SHR) tumor suppressor gene oncogene blood vessel reconstruction |
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