乙肝病毒感染与原发性肝细胞癌的队列研究

目的：探讨HBV感染与原发性肝细胞癌（PHCC）的关系。方法：1992年在PHCC高发地区江苏省海门市建立了90236例的前瞻性研究队列。其中HBsAg（＋）14338例，HBsAg（-）75898例，对每一研究对象进行一项流行病学调查。采集外周静脉血10ml，检测HBsAg及其它相关研究指标，每年随访1次队列成员的生命状况至2003年终止。比较两组人群PHCC死亡密度和PHCC发病年龄的差别。计算相对危险度（RR）、归因危险度（AR）、归因危险度百分比（AR％），应用COX风险比例模型计算HBsAg（＋）在PHCC发生中的风险率比（HR）。结果：研究组与对照组PHCC死亡密度比较RR=15，63，AR：725．32（1／10万人年），AR％=93．60％，男性HR：22，3，95％CI为18．7～26．6，女性HR：37．2，95％CI为19．1～72．5。PHCC年龄组死亡密度的分析结果表明感染HBV可促使PHCC发病年龄提前。

Cohort Study between Hepatitis B Virus Infection and Primary Hepatocellular Carcinoma

Objective:In order to explore the relation between Hepatitis B virus(HBV) infection and primary hepatocellular carcinoma(PHCC).Methods:A prospective cohort study was made of 90236 people in PHCC high risk area of Haimen City in 1992,of them 14338 showed pasitive surface antigen of hepatitis B(HBsAg),and 75898 had negative surface antigen of hepatitis B.An epidemiological suvey was made of every object of study.Blood samples were taken from their veins to detect their HBsAg and other related targets.The vital state of each member was followed up once a year until 2003.Death density was used to express mortality to compare the difference in PHCC death density and in age of PHCC onset between the two groups.RR,AR and AR% were all evaluated.HR of positive HBsAg causing PHCC was measured by using COX mode of risk proportion.Results:According to the comparison in the death density of HCC between the study group and the control group,RR was 16.63;AR,725.32(1/100000 people a year);and AR% 93.60%;male HR,22.3;95% CI,18.7~26.6 while female HR was 37.2;95% and CI,19.1~72.5