Entomological survey and report of a knockdown resistance mutation in the malaria vector Anopheles gambiae from the Republic of Guinea |
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Authors: | P Carnevale P Guibert S Manguin |
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Institution: | a Institut de Recherche pour le Développement (IRD), Ave Agropolis, 34394 Montpellier, France b Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), BP 288, Yaoundé, Cameroun c International SOS, 1 rue du Parc, 92593 Levallois Perret Cedex, Paris, France d Ministère de la Santé, Conakry, Guinea e Institut de Recherche pour le Développement (IRD), Laboratoire d’Immuno-Physiopathologie Virale et Moléculaire, Faculté de Pharmacie, Université Montpellier 1, 15 Ave Charles Flahault, 34093 Montpellier, France |
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Abstract: | The purpose of our entomological survey was to estimate mosquito biodiversity, infectivity rates and insecticide resistance levels in Anopheles species in four study sites in a mining area with high malaria transmission in southeastern Guinea. Anopheles gambiae s.l. (77%) was the most common Anopheles collected followed by An. funestus (20%). The specimens of the An. gambiae complex were predominantly An. gambiae S form (97.6%) with 1.4% of An. gambiae M form found in Kérouané only, and 1% of An. arabiensis which was present in all four study sites. Anopheles gambiae S form and An. funestus were found to be infected with Plasmodium falciparum, with infectivity rates of 4.1% and 4.4% and inoculation rates of 0.60 and 0.19 infected bite/person/night, respectively. In addition, a high level (79%) of the knockdown resistance (kdr) L1014F mutation was reported in the populations of An. gambiae S form. The high malaria transmission that occurs in the prospected area of Guinea requires a long-term vector control programme. However, such a control programme will have to consider the presence of the kdr gene at a surprisingly high level within the dominant vector, which could reduce the expected impact of vector control. |
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Keywords: | Malaria Anopheles gambiae Infectivity rate Insecticide resistance kdr Republic of Guinea |
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