| HPLC法测定槲皮素固体脂质纳米粒的含量 |
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| 引用本文： | 常明泉,杨光义,李发鹏,王刚. HPLC法测定槲皮素固体脂质纳米粒的含量[J]. 中国药事, 2011, 25(8): 779-780,784 |
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| 作者姓名： | 常明泉 杨光义 李发鹏 王刚 |
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| 作者单位： | 1. 湖北医药学院附属太和医院药学部,十堰,442000
2. 湖北医药学院药检学院 |
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| 基金项目： | 湖北省教育厅优秀中青年基金资助项目(编号ku201002110) |
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| 摘 要： | 目的建立HPLC法测定槲皮素固体脂质纳米粒含量的方法。方法色谱柱:Diamonsil C18柱,流动相:甲醇-4.3%乙酸溶液(55∶45),流速:1.0mL.min-1,检测波长:254nm,进样量:20μL,柱温:30℃。结果槲皮素在20.0~200.0μg.mL-1范围内线性关系良好,平均回收率为98.6%,RSD=1.18%,结论本方法快捷、简便、准确、专属性强,可用于槲皮素固体脂质纳米粒的质量控制。
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| 关 键 词： | 槲皮素 固体脂质纳米粒 HPLC 含量测定 |
Determination of Quercetin Solid Lipid Nanoparticles by HPLC |
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| Chang Mingquan,Yang Guangyi,Li Fapeng,Wang Gang. Determination of Quercetin Solid Lipid Nanoparticles by HPLC[J]. Chinese Pharmaceutical Affairs, 2011, 25(8): 779-780,784 |
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| Authors: | Chang Mingquan Yang Guangyi Li Fapeng Wang Gang |
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| Affiliation: | Chang Mingquan,Yang Guangyi,Li Fapeng1 and Wang Gang(Taihe Hospital of Hubei Medical College,Shiyan 442000,1School of Drug Tests,Hubei Medical College) |
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| Abstract: | Objective To establish the determination method of quercetin solid lipid nanoparticles（QUE-SLNs）.Methods HPLC column was Diamonsil C18.Mobile phase： methanol-4.3% acetic acid（55∶45）,flow rate： 1.0mL·min-1,column temperature： 30℃,injection volume： 20μL,detection wavelength： 254nm.Results The linear range of quercetin was 20.0～200.0μg·mL-1.The average recovery was 98.6%,with RSD 1.18%.Conclusion This method is simple,accurate,and feasible.It can be used for quality control of QUE-SLNs. |
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| Keywords: | quercetin solid lipid nanoparticles HPLC determination |
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