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| 大鼠腹腔巨噬细胞释放自由基的直接检测及寒下药物对其影响 | |
| 引用本文： | 赵琪,吴咸中,崔乃强,李继坤. 大鼠腹腔巨噬细胞释放自由基的直接检测及寒下药物对其影响[J]. 中国中西医结合外科杂志, 1997, 0(2) |
| 作者姓名： | 赵琪 吴咸中 崔乃强 李继坤 |
| 作者单位： | 天津市中西医结合急腹症研究所 |
| 摘 要： | 利用电子自旋共振法（ＥＳＲ）直接测定大鼠腹腔巨噬细胞经不同浓度内毒素刺激６０分钟后释放自由基水平的动态改变，及寒下药物清除自由基作用。结果表明，内毒素体外能诱使大鼠腹腔巨噬细胞产生自由基，并呈剂量依赖效应，随内毒素刺激剂量的增加，巨噬细胞产生自由基水平增高（Ｐ均＜０．０５）；以大承气汤为代表的寒下方剂能显著抑制大鼠腹腔巨噬细胞释放自由基（Ｐ＜０．０１），表明寒下方剂能清除自由基，抑制巨噬细胞呼吸爆发的产生。 |
| 关 键 词： | 自由基 电子自旋共振 寒下药 |
Direct Detection of Free Radical Produced by Rat Peritoneal Macrophages and Inhibitory Effect Induced by Hanxia Herbs |
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| Zhao Qi Tianjin Institute of Acute Abdominal Diseases. Direct Detection of Free Radical Produced by Rat Peritoneal Macrophages and Inhibitory Effect Induced by Hanxia Herbs[J]. Chinese Journal of Surgery of Integrated Traditional and Western Medicine, 1997, 0(2) | |
| Authors: | Zhao Qi Tianjin Institute of Acute Abdominal Diseases |
| Abstract: | The level of the LPS induced free radical production in rat peritoneal macrophages was trailed according to the process of electron spin resonance.The kinetic effect of free radical production induced by LPS showed a positive dose dependent manner.The higher the concentration of LPS stimulated,the higher the level of free radical produced.The free radical production was inhibited by the mixture of purgative nature herbs cocultivated with rat peritoneal macrophages ( P< 0.01). |
| Keywords: | free radical electron spin resonance Hanxia herbs |
| 本文献已被 CNKI 等数据库收录！ | |