女贞孕育汤对不孕症子宫内膜组织形态、雌孕激素受体和血管生成因子表达的影响

目的研究养血补肾方药女贞孕育汤对人子宫内膜组织形态学和雌孕激素受体、血管生成因子及其受体表达的影响.方法利用服用女贞孕育汤3个周期的人LH-2时相的子宫内膜活检组织进行组织形态和免疫组织化学的观察.结果服用该汤后的内膜增生反应明显增强,组织增殖活性旺盛,ER、PR、PCNA、VEGF、VEGFR、bFGF/FGF、EGFR、PDGFR共8种观察因子或受体的表达强度均明显增强,表明该汤具有促进子宫内膜生长发育、促进DNA合成、促进血管生成活性的作用.结论补肾填精养血活血的女贞孕育汤对子宫内膜的调节促进作用是助孕作用的基础.

Study of Nuzhen Yunyu Decoction on Histomorphological Endometrium and Expression of Estrogen Receptor and Factors of the Formation of Capillary

Objective To study Nuzhen Yunyu Decoction on endometrium histomorphology and expression of estrogen receptor and factors of the formation of capillary. Methods The histomorphology and immunohistochemistry of endometrium were tested in the phase of LH-2 in subjects treated with Nuzhen Yunyu Decoction for 3 weeks. Results With three weeks Nuzhen Yunyu Decoction treatment, the proliferation of the endometrium significantly increased as well as the histochemical expression of ER, PR, PCNA, VEGF, VEGFR, bFGF/FGF, EGFR and PGFR, which indicated that Nuzhen Yunyu Decoction can promoting the development of endometrium and improving the synthesis of DNA and formation of the capillary. Conclusion Nuzhen Yunyu Decoction can promote pregnancy through its effects on positive regulation on the endometrium.