多巴胺D3受体基因Ser-9-Gly多态性精神分裂症的关联研究

为探讨精神分裂症与多巴胺 D3受体基因 ( dopamine D3receptor gene,DRD3) Ser-9-Gly多态性是否关联。应用PCR-RFLP方法检测了广州地区汉族人群中 1 2 3例家族史阴性、1 1 3例家族史阳性精神分裂症患者、1 6 8例家族史阴性患者父母和 4 7例正常老年人中多巴胺 D3受体基因 Ser-9-Gly多态性 ,并对多巴胺 D3受体基因各等位基因及基因型与精神分裂症进行了相关分析 ,DRD3与精神分裂症、患者性别及家族史均无关联 ( P>0 .0 5 )。提示广州地区汉族人群中DRD3基因 Ser-9-Gly多态性与精神分裂症没有关联。

An association study between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia

The study was to investigate the relationship between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia.Patients with schizophrenia and controls who are the patients' parents or unrelated elderly normal population were genotyped by using polymerase chain reaction and a Bal I restriction fraction length polymorphism.No significant differences in genotypes and alleles frequencies of Ser-9-Gly polymorphism in DRD3 were observed between schizophrenic patients and controls.When patients were divided according to sex,or presence or absence of family history,the differences were still not significant.Our findings do not confirm an association between DRD3 and schizophrenia in Han Chinese.