| 巨细胞病毒感染对动脉粥样硬化的影响 |
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| 引用本文： | 许从峰,陈瑞珍,徐薇,沈燕,葛均波,陈灏珠,郑秀娟,熊思东. 巨细胞病毒感染对动脉粥样硬化的影响[J]. 免疫学杂志, 2003, 19(6): 451-453 |
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| 作者姓名： | 许从峰 陈瑞珍 徐薇 沈燕 葛均波 陈灏珠 郑秀娟 熊思东 |
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| 作者单位： | 复旦大学上海医学院免疫学系,教育部分子医学重点实验室,上海基因免疫与疫苗研究中心,上海,200032;复旦大学附属中山医院心血管病研究所,上海,200032;复旦大学附属中山医院心血管病研究所,上海,200032;复旦大学上海医学院免疫学系,教育部分子医学重点实验室,上海基因免疫与疫苗研究中心,上海,200032 |
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| 基金项目： | 国家重点基础研究发展规划资助项目 (G2 0 0 0 0 5 6 90 3) |
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| 摘 要： | 目的：研究巨细胞病毒(CMV)感染和动脉粥样硬化的关系,并探讨其可能机制。方法：通过一个大样本从血清流行病学(ELISA检测患者血清中抗CMV的IgG抗体)和分子生物学(PCR检测动脉粥样硬化病变中CMV特异性基因)方面探讨巨细胞病毒感染和动脉粥样硬化的关系,并检测CMV感染对内皮细胞趋化因子表达的影响。结果：动脉粥样硬化组血清中CMV的阳性率显著高于非动脉粥样硬化组(分别为82．2％和61．0％,P=0．02);而且动脉粥样硬化斑块中HCMV基因出现率显著高于正常血管组织(13／15和2／7,P=0．01);CMV感染还可上调内皮细胞：ECV-304表达MCP-1。结论：CMV感染参与动脉粥样硬化的形成和发生,这可能与CMV上调内皮细胞趋化因子表达有关。
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| 关 键 词： | 巨细胞病毒 动脉粥样硬化 趋化因子 |
| 文章编号： | 1000-8861(2003)06-0451-03 |
| 修稿时间： | 2002-12-24 |
CMV infection were involved in the pathogenesis of atherosclerosis |
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| XU Cong-feng ,,CHEN Rui-zhen ,XU Wei ,SHEN Yan ,GE Jun-bo ,CHEN Hao-zhu ,ZHENG Xiu-juan ,XIONG Si-dong. CMV infection were involved in the pathogenesis of atherosclerosis[J]. Immunological Journal, 2003, 19(6): 451-453 |
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| Authors: | XU Cong-feng CHEN Rui-zhen XU Wei SHEN Yan GE Jun-bo CHEN Hao-zhu ZHENG Xiu-juan XIONG Si-dong |
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| Affiliation: | XU Cong-feng 1,2,CHEN Rui-zhen 2,XU Wei 1,SHEN Yan 1,GE Jun-bo 2,CHEN Hao-zhu 2,ZHENG Xiu-juan 1,XIONG Si-dong 1 |
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| Abstract: | Objective To study the relationship between CMV infection and atherogenesis and the putative mechanism.Method To detect CMV IgG of subject serum with ELISA and the existence of CMV IE gene in the atherosclerotic plaque by PCR. The expression of chemokines in endothelial cells after infection with CMV was also studied.Results The positive rate of CMV IgG was significantly higher in athe- rosclerosis group than that in non-atherosclerosis group (82.2% vs 61.0%, P=0.02); HCMV-specific gene in atherosclerotic plaque was much more frequently detected than that in normal vascular tissue(13/15 vs 2/7, P=0.01). CMV infection can up-regulate the expression of chemokines in endothelial cells ECV-304.Conclusion CMV infection was involved in the pathogenesis of atherosclerosis, which might be me- diated by up-regulated expression of chemokines in ECV-304 after CMV infection. |
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| Keywords: | Cytomegalovirus Atherosclerosis Chemokine |
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