70例开颅术后颅内感染患者相关危险因素分析

目的探讨开颅术患者术后颅内感染的相关危险因素,为临床预防和控制颅内感染提供依据。方法选择本院2006—2012年接受开颅手术的患者1 356例,分析颅内感染发生率及颅内感染相关危险因素。结果发生颅内感染患者共70例,感染率为5.16%。单因素分析结果显示,观察组(发生颅内感染者)高温季节、高龄、污染手术、长时间手术(≥4 h)、短期2次以上手术、术后脑脊液漏、长时间脑室外引流、急诊手术等比例高于对照组(P<0.05);多因素Logistic分析结果显示,长时间手术(≥4 h)、短期2次以上手术、手术术后脑脊液漏、长时间脑室外引流为开颅术后颅内感染的危险因素。结论长时间手术(≥4 h)、短期2次以上手术、手术术后脑脊液漏、长时间脑室外引流为开颅术后颅内感染的危险因素,临床工作中应采取积极的应对措施。

Analysis of risk factors of 70 patients with intracranial infection after cranial surgery

Objective To explore the risk factors associated with craniotomy intracranial infection,providing references for clinical prevention and control of intracranial infection.Methods A total of 1356 patients that underwent cranial surgery were chosen,and the rate and the risk factors of intracranial infection were analyzed.Results ① There were 70 infection cases,the infection rate being 5.16%.Univariate analysis showed that the rates of hot season,senility,pollution surgery,prolonged surgery(≥4 h),two plus operations in a short term,postoperative cerebrospinal fluid leakage,prolonged ventricular drainage,emergency surgery were higher in the observation group than in the control group(P<0.05).② Multivariate Logistic analysis showed that prolonged surgery(≥4 h),two plus operations in a short term,postoperative cerebrospinal fluid leakage,prolonged ventricular drainage were risk factors of craniotomy intracranial infection.Conclusion Long time surgery(≥4 h),two plus operations in a short term,postoperative cerebrospinal fluid leakage,prolonged ventricular drainage are craniotomy intracranial infection risk factors.Positive countermeasures should be taken in clinical practice.