多烯磷脂酰胆碱联合二甲双胍治疗非酒精性脂肪肝的临床观察

目的 探讨多烯磷脂酰胆碱联合二甲双胍治疗非酒精性脂肪肝的疗效.方法 将60例非酒精性脂肪肝患者按随机分为两组,治疗组和对照组分别30例.治疗组采用多烯磷脂酰胆碱联合二甲双胍治疗,对照组单用多烯磷脂酰胆碱治疗.观察两组患者治疗前后肝功能指标[丙氨酸转氨酶(AIT)、天冬氨酸转氨酶(AST)]、血脂指标[三酰甘油(TC)、总胆固醇(TC)]的变化及治疗后临床疗效等情况.两组治疗期间均不用其他保肝降酶和降血脂类药物.结果 治疗组肝功能、血脂各指标显著下降,与对照组比较,差异有统计学意义(P<0.05);治疗组、对照组总有效率分别为76.6%、63.3%,两组比较差异有统计学意义(P<0.05).结论 多烯磷脂酰胆碱联合二甲双胍治疗非酒精性脂肪肝疗效显著.

Curative effects of polyene phosphatidyl choline in combination with metformin on non-alcoholic fatty liver disease

Objective To explore the clinical effects of polyene phosphatidyl choline in combination with metformin on non-alcoholic fatty liver disease(NAFLD).Methods Sixty patients with NAFLD were randomly divided into 2 groups to the mumber table method:treatment group(n=30)and control group(n=30).The patients in control group only received polyene phos phatidyl choline,but the patients in treatment group were treated with polyene phosphatidyl choline in combination with metformin.The levels of alanine transaminase(AlT),aspartate aminotrasferase(AST),triglyceride(TG)and total cholesterol(TC)were determined before treatment and after treatment and cliniea1 curative effect in after treatment.Any other iiver function-protecting and lipid-lowering drugs were excluded during the treatment period.Results Compared with the control 1iver function,blood 1ipid profiles were significantly improved in treatment group(P<0.05).The total effective rate of clinical efficacy in treatment group(76.6%)was higher than that in control group(63.3%)(P<0.05).Conclusion Polyene phosphatidyl choline combined with metformin has remarkable curative effects on NAFLD.