吉西他滨联合奥沙利铂治疗晚期复发转移卵巢癌的临床观察

目的探讨吉西他滨联合奥沙利铂治疗晚期复发转移卵巢癌的疗效及不良反应。方法本组21例患者给予吉西他滨和奥沙利铂治疗,连用2个周期后进行影像学检查、CA125评价疗效和观察不良反应。结果总有效率38.1%,恶心呕吐发生率17例(80.9%),神经毒性、感觉异常占13例(61.9%),白细胞下降15例(71.4%);血小板下降13例(61.9%);红细胞下降9例(42.9%)。结论吉西他滨联合奥沙利铂治疗晚期复发转移卵巢癌患者疗效确切,毒性反应低,耐受好,生存质量明显提高。

The clinical observation of Gemcitabine and oxaliplatin in relapse and metastasis ovarian cancer

Objective To research the effectiveness and adverse reaction of gemcitabine and oxaliplatin in relapse and metastasis ovarian cancer.Methods A total of 21 patients in the group were trated with gemcitabine and t oxaliplatin,after two cycle,they rpeated imaging、CA125 and researched effectiveness and adverse reaction.Results The total cure rates of these drugs was 38.1%,nausea and vomiting incidence was 17 patients(80.9%),neurotoxicity and cacesthesia was 13 patients(61.9%),leucocyte decline was 15 patients(71.4%),blood cell decline was 13 patients(61.9%),red blood cell decline was 9 patients(42.9%).Conclusion Gemcitabine and oxaliplatin treated relapse and metastasis ovarian cancer had good effectiveness and low toxicity,the tolerance was good and quality of life was improved.