黄芪皂苷甲的抗炎和降压作用

黄芪皂苷甲是从中药黄芪中分得的成分。体外实验中,对兔红细胞膜有稳定作用。口服或静脉注射均能对抗组胺和5-羟色胺引起的大鼠毛细血管通透性增加。口服可抑制角叉菜胶引起的大鼠踺底肿胀。静脉注射引起麻醉猫或大鼠的血压明显下降,此作用不为苯海拉明或阿托品所阻断。用恒压泵法测外周血管阻力,股动脉给药可引起猫后肢血管扩张。

EFFECTS ON BLOOD PRESSURE AND INFLA MMATION OF ASTRAGALUS SAPONIN 1,A PRINCIPLE ISOLATED FROM ASTRAGALUS MEMBRANACEUS BGE

This paper reports the pharmacological activities of Astragalus saponin 1, a principle isolated from "Huang Oi" (Astragalus membranaceus Bge).Astragalus saponin 1 Was shown to produce anti-inflammatory action and to lower blood pressure. When given intravenously (5 mg/kg) or orally (50 mg/kg) the component inhibited the increase in vascular permeability caused by 5-HT and histamine. The reduction rate of inflammatory action was 55.93% and 38.02% respectively. If Astragalus saponin 1 was administered orally at a doses of 25 mg/kg, 50 mg/ kg or 100 mg/kg, marked reduction in carrageenin-induced edema of the hind paw of rats was noted-. The inhibitory activity was shown to be dose-dependent. Lowering of blood pressure was demonstrated by intravenous administration of the saponin 15mg or 10mg/kg in anesthetized cats or rats. The resistance of the vascular bed of hind limb was reduced when 0.25 mg/kg Astragalus saponin 1 of was injected close-arterially to cats.