前炎止痛贴联合前列清瘀汤治疗慢性前列腺炎疗效评价及对EPS中Zn2+和PSA水平的影响

目的观察前炎止痛贴联合前列清瘀汤治疗慢性前列腺炎的临床疗效及对前列腺液中锌离子(Zn2+)和前列腺特异性抗原(prostate-specific antigen,PSA)水平的影响。方法选取2018年1月至10月湖南中医药大学第一附属医院诊治的160例符合标准的慢性前列腺炎(湿热夹瘀型)患者为研究对象,将其随机分为脐贴+中药组、脐贴组、中药组、宁泌泰胶囊组4组,每组40例患者,比较各组患者治疗前后前列腺液中Zn2+和PSA水平及其临床疗效。结果①四组患者治疗后疗效比较存在差异,脐贴+中药组患者治疗后的总有效率(92.5%)明显优于其他各组患者,其差异均具有统计学意义(均P<0.05);②四组患者治疗后前列腺液中Zn2+和PSA水平均明显高于治疗前,其差异均具有统计学意义(均P<0.05)。结论前炎止痛贴联合前列清瘀汤治疗慢性前列腺炎,能够明显改善患者临床症状,治疗效果优于单纯中药治疗、单纯脐贴治疗和口服宁泌泰治疗,其机制可能与提高前列腺按摩液(expressed prostatic secretion,EPS)中Zn2+和PSA水平有关。

Efficiency of Qianyanzhitong plaster combined with Qianlieqingyu decoction in the treatment of chronic prostatitis and its effect on the levels of zinc and PSA in EPS

Objective To observe the clinical curative effect of Qianlieqingyu decoction combined with Qianyanzhitong plaster in the treatment of chronic prostatitis and its effect on the levels of zinc and prostate-specific antigen(PSA) in expressed prostatic secretions(EPS). Methods The 160 patients with chronic prostatitis(damp heat with occulation), who were admitted to our hospital from January to October 2018, were randomly divided into 4 groups with 40 cases in each, i.e. umbilical plaster combined with Chinese medicine group, umbilical plaster group, Chinese medicine group and Ningbitai capsule group. The levels of zinc and PSA in the EPS before and after treatment in each group and the clinical efficacy were compared. Results ①There were differences in the efficacy of the 4 groups after treatment. The total effective rate of the umbilical plaster combined with Chinese medicine group(92.5%) was significantly higher than that of the other groups(all P<0.05);②The levels of zinc and PSA in the EPS of the four groups was significantly higher than those before treatment, with statistically significant differences(all P<0.05). Conclusions Qianyanzhitong plaster combined with Qianlieqingyu decoction can significantly improve the clinical symptoms of patients with chronic prostatitis, with better effect than that of the other 3 groups and its mechanism may be related to improving zinc and PSA levels in EPS.