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| 垂体腺瘤细胞增殖、凋亡与侵袭性生长关系的研究 | |
| 引用本文： | 吴群,张宏,刘伟国,张建民,吕世亭. 垂体腺瘤细胞增殖、凋亡与侵袭性生长关系的研究[J]. 浙江医学, 2002, 24(10): 584-585,588 |
| 作者姓名： | 吴群 张宏 刘伟国 张建民 吕世亭 |
| 作者单位： | 310009 杭州，浙江大学医学院附属第二医院神经外科 |
| 摘 要： | 目的 探讨垂体腺瘤细胞的增殖、凋亡与侵袭性生长的关系。 方法 对37例侵袭性垂体腺瘤及30例非侵袭性垂体腺瘤患者采用免疫组化SP法测定增殖细胞核抗原(PGNA)、B细胞淋巴瘤(Bcl-2)及相关基因(Bax)蛋白产物的表达。 结果 侵袭性垂体腺瘤患者与非侵袭性垂体腺瘤患者比较 ,PCNA、Bcl-2和Bax的表达水平均明显增高(均P<0.05)。结论 垂体腺瘤的侵袭性生长与PCNA、Bcl-2和Bax的异常表达有关 ,是肿瘤细胞不断增殖和凋亡抑制的结果 |
| 关 键 词： | 细胞增殖 垂体腺瘤 细胞凋亡 侵袭性 免疫组织化学 |
The cell proliferation, apoptosis and invasive behavior of pituitary adenoma |
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| WU Qun,ZHANG Hong,LIU Weiguo,et al.. The cell proliferation, apoptosis and invasive behavior of pituitary adenoma[J]. Zhejiang Medical Journal, 2002, 24(10): 584-585,588 | |
| Authors: | WU Qun ZHANG Hong LIU Weiguo et al. |
| Affiliation: | WU Qun,ZHANG Hong,LIU Weiguo,et al.Department of Neurosurgery,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China |
| Abstract: | Objective To investigate cell proliferation,apoptosis and invasive behavior in pituitary adenoma.Methods The expressions of proliferation cell nuclear antigen (PCNA),B cell leukemia/lymphoma-2(Bcl-2) and Bcl-2 associated X protein (Bax) were examined by immunohistochemical SP methods in 37 cases of invasive pituitary adenomas and 30 cases of noninvasive pituitary adenomas.Results Expression of PCNA,Bcl-2 and Bax were significantly higher in invasive pituitary adenomas than those in noninvasive pituitary adenomas (P<0.05).Conclusion The invasive potential of pituitary adenoma might be correlated with abnormal protein expressions of PCNA,Bcl-2 and Bax,and this might be the result of constantly proliferation and suppression of apoptosis in tumor cells. |
| Keywords: | Pituitary adenoma Proliferation Apoptosis Invasiveness |
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