A live attenuated turkey rhinotracheitis virus vaccine. 1. Stability of the attenuated strain |
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| Authors: | J K Cook M M Ellis C A Dolby H C Holmes P M Finney M B Huggins |
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| Affiliation: | AFRC Institute for Animal Health, Houghton Laboratory, Houghton, Huntingdon, Cambridgeshire, England. |
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| Abstract: | Compared with the severe clinical disease caused by two virulent strains of turkey rhinotracheitis virus (TRTV), an attenuated strain has been shown to cause only slight respiratory infection in 7-day-old TRT-free turkey poults, yet still to be capable of stimulating TRT antibodies and of protecting the poults against challenge with virulent TRTV 21 days later. The stability of the attenuation during 12 turkey-turkey passages of the strain has been demonstrated; the poult passaged and prepassaged strains causing only mild respiratory signs even when bacteria, known to be associated with severe outbreaks of TRT in the field, were included in the inoculum. |
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