左氧氟沙星在肾移植中的应用

目的 :评价中等剂量左氧氟沙星用于肾移植术后预防及治疗感染的安全性及不良反应。方法 :回顾性分析 130例肾移植术后病人 ,其中 65例(男性 4 4例 ,女性 2 1例 ;年龄 4 4a±s 8a)采用左氧氟沙星 2 0 0mg ,iv ,gtt ,q 12h。另 65例 (男性 38例 ,女性 2 7例 ;年龄 4 2a± 11a)采用头孢噻肟 3g ,iv ,gtt ,q 12h ,为对照组。 2组疗程均为 7～ 14d。结果 :左氧氟沙星组治疗总有效率 95% ,切口Ⅰ期愈合率 97% ,不良反应发生率 5%。头孢噻肟组分别为 94 % ,95%和 6%。 2组差异无显著意义 (P >0 .0 5)。结论 :中等剂量的左氧氟沙星用于肾移植术后预防及治疗感染与头孢噻肟同样是安全可靠的

Clinical use of levofloxacin in kidney transplantation

AIM: To evaluate the safety and adverse reactions of levofloxacin in preventing and treating infection after kidney transplantation. METHODS: The treating materials in one hundred and thirty patients after kidney transplantation were retrospectively analysed. The therapeutic group of 65 patients received levofloxacin(M 44,F 21;age 44 a±s 8 a) 200 mg, iv,gtt,q 12 h and the control group of 65 patients (M 38,F 27;age 42 a±11 a) received cefotaxime 3 g,iv,gtt,q 12 h. The treatment course of two groups were all 7～14 d. RESULTS: The treatment efficiency rate of levofloxacin was 95 %, the wound healing rate was 97 %, the rate of adverse reactions was 5 %; the treatment efficiency rate of cefotaxime was 94 %, the rate of wound healing was 95 %, the rate of adverse reactions was 6 %. There was no significant difference between two groups (P> 0.05 ). CONCLUSION: It is safe and reliable as cefotaxime to prevent and treat infection after kidney transplantation with the middoses levofloxacin.