Pharmacological evaluation of the dichloromethanol extract from Inula crithmoides L. |
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Authors: | M D Barrachina R Bello J Esplugues I Sanz E Primo Yúfera |
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Abstract: | The pharmacological effect of the dichloromethanol extract of Inula crithmoides L. was analysed in in vitro and in vivo models. The extract dose-dependently decreased arterial blood pressure and furthermore it showed low acute toxicity, CNS depressor activity and analgesic and antiinflammatory effects. Preincubation of the guineapig ileum and rat duodenum (100 μg/mL) produced a significant reduction in the contractile effects of histamine and acetylcholine and a concentration-related inhibition of the effects of serotonin. Following further fractionation the methylene chloride/acetone (50/50) fraction caused a significant decrease in motor activity and significantly reduced the threshold of pain chemical stimulus. |
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Keywords: | Inula crithmoides L effect on CNS analgesic-antiinflammatory effect blood pressure smooth muscle plant extract |
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