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Orthotopic placement of the dunning R3327 AT-3 prostate tumor in the copenhagen X fischer rat
Authors:Marvin Rubenstein  Robert Saffrin  Michael Shaw  Sergey Muchnik  Patrick Guinan
Abstract:Orthotopic placement of in vitro propagated Dunning R3327 AT-3 tumor cells resulted in a greater percentage of tumor takes and a two-fold shift in the exponential growth curve compared to flank implantation. The orthotopic tumor appeared to disseminate preferentially to regional lymph nodes, rather than to the lungs which is characteristic of flank tumors. The results suggest an important role of stromal-epithelial interactions in the growth of this tumor. © 1995 Wiley-Liss, Inc.
Keywords:orthotopic  Dunning R3327 AT-3  prostate tumor  Copenhagen X Fischer rat
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