| 水合氯醛和苯磺酸阿曲库铵对大鼠坐骨神经复合肌肉动作电位的影响 |
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| 引用本文： | 孟祥虎,臧光辉,樊龙昌,肖海涛,权伟合,刘继红,张传汉,罗爱林,田玉科.水合氯醛和苯磺酸阿曲库铵对大鼠坐骨神经复合肌肉动作电位的影响[J].中国药师,2012(11):1544-1547. |
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| 作者姓名： | 孟祥虎 臧光辉 樊龙昌 肖海涛 权伟合 刘继红 张传汉 罗爱林 田玉科 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院泌尿外科 武汉 430030；;华中科技大学同济医学院附属同济医院泌尿外科 武汉 430030；;华中科技大学同济医学院附属同济医院麻醉科；;华中科技大学同济医学院解剖学系;华中科技大学同济医学院附属同济医院泌尿外科 武汉 430030；;华中科技大学同济医学院附属同济医院泌尿外科 武汉 430030；;华中科技大学同济医学院附属同济医院麻醉科；;华中科技大学同济医学院附属同济医院麻醉科；;华中科技大学同济医学院解剖学系 |
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| 基金项目： | 国家自然科学基金资助项目（编号：30901404） |
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| 摘 要： | 目的:研究水合氯醛和苯磺酸阿曲库铵对大鼠坐骨神经复合肌肉动作电位（compound muscle action potential,CMAP）的影响。方法:成年SD大鼠20只,随机分为2组（n=10）:水合氯醛组（C组）和水合氯醛复合苯磺酸阿曲库铵组（CA组）。2组腹腔注射7%水合氯醛350 mg·kg-1麻醉,给予水合氯醛后8 min时CA组腹腔注射苯磺酸阿曲库铵2.5μg·kg-1。于给予水合氯醛8 min时刺激坐骨神经,记录其所支配的腓肠肌的CMAP。刺激强度为0.50 v、0.55 v、0.60 v,波宽0.05 ms,频率10 Hz,每隔5 min重复上述刺激。结果:与8 min时比较,0.50 v,0.55 v,0.60 v强度下C组CMAP的峰峰值及潜伏期均无明显变化（P均>0.05）;CA组与8 min时比较,0.50,0.55及0.60 v强度下23～43 min时的CMAP峰峰值降低（P<0.05或0.01）,0.50 v强度下38 min的CMAP潜伏期延长（P<0.05）,0.55 v,0.60 v强度下,23～43 min的CMAP潜伏期延长（P<0.05或0.01）。结论:水合氯醛对大鼠坐骨神经CMAP无明显影响;而复合肌松药苯磺酸阿曲库铵后对CMAP有一过性的抑制作用。
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| 关 键 词： | 水合氯醛 苯磺酸阿曲库铵 肌松药 复合肌肉动作电位 周围神经 |
| 收稿时间： | 2012/7/23 0:00:00 |
| 修稿时间： | 2012/8/24 0:00:00 |
Effects of Chloral Hydrate and Atracurium Besilate on Compound Muscle Action Potential of Sciatic Nerves in Rats |
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| Meng Xianghu,Zang Guanghui,Fan Longchang,Xiao Haitao,Quan Weihe,Liu Jihong,Zhang Chuanhan,Luo Ailin and Tian Yuke.Effects of Chloral Hydrate and Atracurium Besilate on Compound Muscle Action Potential of Sciatic Nerves in Rats[J].China Pharmacist,2012(11):1544-1547. |
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| Authors: | Meng Xianghu Zang Guanghui Fan Longchang Xiao Haitao Quan Weihe Liu Jihong Zhang Chuanhan Luo Ailin and Tian Yuke |
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| Institution: | Department of Urology, Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology, Wuhan, 430030, China;Department of Urology, Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology, Wuhan, 430030, China;Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;Department of Anatomy, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;Department of Urology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;Department of Urology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;Department of Anesthesiology,Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;Department of Anatomy, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China |
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| Abstract: | |
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| Keywords: | Effects of Chloral Hydrate and Atracurium Besilate on Compound Muscle Action Potential of Sciatic Nerves in Rats |
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