Effect of estradiol and progesterone on muscle weight and acetylcholine receptors in “myasthenic” rats |
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| Authors: | G Th H Van Kempen Dr P C Molenaar |
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| Institution: | (1) Department of Physiology, University of Leiden, Leiden, The Netherlands;(2) Present address: Physiological Pharmacology Group, Sylvius Laboratory, Post Box 9503, 2300 RA Leiden, The Netherlands |
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| Abstract: | Summary Clinical evidence suggests that endocrinal factors are involved in fluctuations of the symptoms of women with myasthenia gravis. We studied the effect of estradiol and progesterone in an animal model for myasthenia gravis in rats. Although it was found that the mass of muscles was dependent on sex, and in female rats affected by estradiol, the number of acetylcholine receptors in these muscles was independent of sex and hormone administration. Sex hormones failed to influence the severity of muscle weakness in myasthenic rats. |
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| Keywords: | Acetylcholine receptors estradiol myasthenia gravis neuromuscular junction progesterone |
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