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| HLA配型不合造血干细胞移植治疗血液病 | |
| 引用本文： | 肖毅,张东华,张义成,黄伟,黄亮,周剑峰,孙汉英,刘文励. HLA配型不合造血干细胞移植治疗血液病[J]. 华中科技大学学报(医学版), 2008, 37(2): 262-265. DOI: 10.3870/j.issn.1672-0741.2008.02.033 |
| 作者姓名： | 肖毅 张东华 张义成 黄伟 黄亮 周剑峰 孙汉英 刘文励 |
| 作者单位： | 华中科技大学同济医学院附属同济医院血液科,武汉,430030 |
| 摘 要： | 目的 评价亲缘人类白细胞抗原(HLA)配型不合造血干细胞移植(HSCT)治疗血液病的疗效和并发症.方法 对12例血液病患者进行了亲缘HLA至少1个位点不合的HSCT.预处理分别采用改良Bu/Cy ATG、Flu Cy ATG、Flu Bu ATG、Ara-C Bu Flu ATG方案.采用环孢素A(CsA)、短疗程甲氨蝶呤(MTX)、霉酚酸酯(MMF)的三联方案预防急性移植物抗宿主病(aGVHD),对2例患者加用了CD25单抗.结果 患者移植后造血均顺利恢复,除1例骨髓增生异常综合征伴骨髓纤维化患者植入失败自身恢复外,均达完全供者型植入.10例发生aGVHD(10/12),其中Ⅰ度4例,Ⅱ度3例,Ⅲ度1例,Ⅳ度2例.在可供评价的9例患者中,5例发生慢性GVHD(cGVHD),其中局限型3例,广泛型2例.巨细胞病毒(CMV)感染5例,其中1例为CMV间质性肺炎.死亡4例,其中2例死于肺部感染,1例死于肠道Ⅳ度aGVHD,1例死于多器官功能衰竭.中位随访时间239(72～570) d,7例无病生存,1年预计总生存率(66.7±2.3)%,1年预计无病生存率(58.3±2.2)%,仍在继续随访中.结论 亲缘HLA配型不合HSCT是治疗血液病的有效方法之一,须警惕移植后GVHD及机会性感染的发生. |
| 关 键 词： | 人类白细胞抗原 造血干细胞移植 血液病 移植物抗宿主病 |
| 修稿时间： | 2006-12-12 |
Treatment of Haematological Diseases by Transplantation of Hematopoietic Stem Cells from HLA-mismatched Related Donors |
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| Xiao Yi,Zhang Donghua,Zhang Yicheng et al. Treatment of Haematological Diseases by Transplantation of Hematopoietic Stem Cells from HLA-mismatched Related Donors[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2008, 37(2): 262-265. DOI: 10.3870/j.issn.1672-0741.2008.02.033 | |
| Authors: | Xiao Yi Zhang Donghua Zhang Yicheng et al |
| Affiliation: | Xiao Yi,Zhang Donghua,Zhang Yicheng et al Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430030 |
| Abstract: | Objective To explore the effectiveness and complications of hematopoietic stem cell transplantation(HSCT) from human leukocyte antigen(HLA)-mismatched related donors in the treatment of haematological diseases.Methods Twelve patients with haematological diseases received HSCT from HLA-one-locus-mismatched related donors.They received conditioning regimens of improved busulfan/cyclophosphamide+antithymocyte globulin(ATG),cyclophosphamide+fludarabine+ATG,fludarabine+busulfan+ATG,cytarabine+busulfan+fludarabin... |
| Keywords: | human leukocyte antigen hematopoietic stem cell transplantation haematological diseases graft versus host disease |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |