Increased Frequency of HL-A8 in Sjogren's Syndrome |
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| Authors: | M. Eric Gershwin Paul I. Terasaki Robert Graw Thomas M. Chused |
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| Affiliation: | Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism &Digestive Diseases, the National Cancer Institute, Bethesda, Maryland Clinical Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland Department of Surgery, University of California at Los Angeles, California, U.S.A. |
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| Abstract: | ![]()
The histocompatibility antigen, HL-A8, was found to be elevated in patients with Sjogren's syndrome. Among 24 patients, the frequency of HL-A8 was 58% compared to 21% among controls (P < 0.001 after correction). With the addition of this disorder to the list of other autoimmune diseases associated with HL-A8, it now seems possible to postulate a single basis autoimmune defect gene in high linkage disequilibrium with HL-A8. |
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