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| 半边旗有效成分5F注射液体内外抗肿瘤药理作用研究 | |
| 引用本文： | 戴滨,崔燎,吴铁,汤南,梁念慈,邓亦峰. 半边旗有效成分5F注射液体内外抗肿瘤药理作用研究[J]. 中国药理学通报, 2003, 19(5): 508-511 |
| 作者姓名： | 戴滨 崔燎 吴铁 汤南 梁念慈 邓亦峰 |
| 作者单位： | 广东医学院药理学教研室·广东天然药物研究与开发实验室,湛江,524023 |
| 基金项目： | 国家自然科学基金资助课题 (No 3 9870 90 0 )，广东省科委重大科技攻关项目 (No 962 2 0 0 70 0 2 ) |
| 摘 要： | 目的 观察半边旗有效成分 5F注射液体外体内抗瘤活性、急性毒性作用及其对免疫器官的影响。方法 用MTT法观察 5F注射液对SPCA 1,K5 6 2瘤株的体外抗肿瘤作用 ;采用荷瘤小鼠瘤重、抑瘤率检测 5F注射液对小鼠移植性肿瘤S180、HepA肝癌的抑制作用 ;通过检测LD50 、胸腺指数、肝脏指数、脾脏指数、白细胞数等指标观察 5F注射液的急性毒性及对其免疫器官的影响。结果 5F注射液对SP CA 1,K5 6 2瘤株有显著的体外抗肿瘤作用 ;对荷瘤小鼠肝癌HepA、S180在体内也有抗肿瘤活性 ,5F注射液的半数致死量 (LD50 )为 4 14 4mg·kg-1。结论 5F注射液具有一定的体内体外抗肿瘤活性 ,同时对免疫功能有一定抑制作用。 |
| 关 键 词： | 半边旗 二萜类化合物 MTT法 K562 SPCA-1 小鼠移植性肿瘤 |
| 文章编号： | 1001-1978(2003)05-0508-04 |
| 修稿时间： | 2002-11-12 |
Study on the anti-tumor effect of utility component extracted from Pteris semipinnata L in vitro and in vivo |
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| DAI Bin,CUI Liao,WU Tie,TANG Nan,LIANG Nian-Ci,DENG Yi-Feng. Study on the anti-tumor effect of utility component extracted from Pteris semipinnata L in vitro and in vivo[J]. Chinese Pharmacological Bulletin, 2003, 19(5): 508-511 | |
| Authors: | DAI Bin CUI Liao WU Tie TANG Nan LIANG Nian-Ci DENG Yi-Feng |
| Abstract: | AIM To study the effect of anti-tumor and toxicity of 5F in vitro and in vivo and the effect on the mouse immune organ. METHODS Cytotoxicity assay was tested by MTT method. Mice neoplasia weight, anti-tumor rate, thymus exponent,liver exponent, spleen exponent and leucocyte number were applied to detect the inhibition on S180 and hepatocarcinoma in mouse RESULT 5F has the activity on anti-tumor in vitro and in vivo and decrease the thymus exponent of mouse loaded with tumor. CONCLUSION The parenteral solution of 5F has the effect on anti-tumor and reduced immunological function. |
| Keywords: | Pteris semipinnata L terpenoid MTT method K562 SPCA-1 mice transplatation tumor |
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