Perfusion MRI using dynamic-susceptibility contrast MRI: quantification issues in patient studies

OBJECTIVES: Measurement of perfusion accurately, noninvasively, and with good spatial resolution offers the chance to characterize abnormal tissue in many clinical conditions. Dynamic-susceptibility contrast (DSC) MRI, also known as bolus-tracking MRI, is a dynamic MRI method to measure perfusion and other related hemodynamic parameters. This review article describes the principles involved in perfusion quantification using DSC-MRI as well as discusses the main issues affecting its quantification in patient studies. CONCLUSIONS: It is shown that DSC-MRI is a very powerful technique that provides important information regarding cerebral hemodynamics. The relatively high contrast-to-noise ratio, fast acquisition, and wealth of information available have made DSC-MRI the most commonly used MRI technique for the rapid assessment of the brain hemodynamics in clinical investigations. While very important advances have been achieved in the last 2 decades, there are still some remaining limitations that users should be aware of to avoid misinterpretation of the findings and to make the most of the invaluable information provided by perfusion MRI.