| 在非溃疡性消化不良中ELISA法测抗幽门螺旋杆菌抗体的临床意义 |
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| 引用本文： | 杨昭徐,卞宗芳,候曼芩,田筱玲,陈晶晶,庄弢,蒋秀高.在非溃疡性消化不良中ELISA法测抗幽门螺旋杆菌抗体的临床意义[J].首都医学院学报,1992(4). |
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| 作者姓名： | 杨昭徐 卞宗芳 候曼芩 田筱玲 陈晶晶 庄弢 蒋秀高 |
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| 作者单位： | 首都医学院附属北京天坛医院内科消化组，首都医学院附属北京天坛医院内科消化组，首都医学院附属北京天坛医院内科消化组，首都医学院附属北京天坛医院内科消化组，中国预防医科院流行病学微生物学研究所，中国预防医科院流行病学微生物学研究所，中国预防医科院流行病学微生物学研究所 |
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| 摘 要： | 非溃疡性消化不良(NUD, non-ulcer dyspepsia)是常见症候群,其病因尚未完全明了。NUD中幽门螺旋杆菌(HP Helicobacter Pylori)相关性胃炎占很大比例。针对该菌产生之抗体反应,应用酶联免疫法(ILISA)检测了335例NUD患者血清抗-HP抗体。其中208例为经细菌培养及(或)组织学检查证实的HP相关性胃炎,对其中164例进行前瞻性随机安慰剂对照研究,以评价胶态次枸橡酸铋加氟哌酸治疗效果.治疗组与安慰剂组HP清除率分别为69％与6％(P<0.01)。HP清除后患者胃粘膜炎症好转或消除,症状明显减轻,抗-HP抗体滴度下降。
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| 关 键 词： | 非溃疡性消化不良 幽门螺旋杆菌 酶联免疫法 胶态次枸椽酸铋 氟哌酸 |
Clinical Significance of an ELISA to Detect Anti Helicobacter Pylori in Non-ulcer Despepsia |
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| Yang Zhaoxu,Bian Zongfang,Hou Manqin,Tian Xiaoling.Clinical Significance of an ELISA to Detect Anti Helicobacter Pylori in Non-ulcer Despepsia[J].Journal of Capital University of Medical Sciences,1992(4). |
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| Authors: | Yang Zhaoxu Bian Zongfang Hou Manqin Tian Xiaoling |
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| Institution: | Yang Zhaoxu,Bian Zongfang,Hou Manqin,Tian Xiaoling Department of Internal Medicine,Beijing Tiantan Hospital,Capital Institute of Medicine Chen Jingjing,Zhuang Tao,Jiang Xiugao Institute of Epdemiology and Microbiology,Chinese Academy of Proventre |
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| Abstract: | Non-ulcer dyspepsia(NUD) is a common complaint. Little is known about the patho- genesis of the syndrome. It is intriguing to note the high incidene of helicobacter pylori(HP) infection in NUD. which is associated with a local antibody response directed against the or- ganism. An enzyme-linked immunosorbent assay (ELISA) detection of Ig G antibodies a- gainst HP was used to examine sera from 335 patients with NUD. 208 patients had HP-asso- ciated gastritis according to culture or histology. 164 patients with NUD were studied in a prospective randomized placebocontrolled study to assess the effieacy of colloidol bismuth subcitrate (CBS, 0. 11 qid, for 1 month) plus norfloxacin (0. 2 tid, for 1 month). HP was cleared in 85% of CBS-Norfloxacin-treated patients compared with only 6% placebo(P< 0. 01). Both acute and chronic inflammation improved in patients cleared of bacteria. Clear- ance of HP and histological improvement was associated with a significant decrease in symp- toms and antibody titres to HP after treatment. |
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| Keywords: | non-ulcer dyspepsia helicobacter pylori ELISA gastritis colloidal bismuth subeitrate norfloxacin |
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