| HPLC法同时检测金银花露中6种防腐剂含量 |
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| 引用本文： | 张瑾,丁晴,栾洁.HPLC法同时检测金银花露中6种防腐剂含量[J].海峡药学,2013,25(9):80-82. |
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| 作者姓名： | 张瑾 丁晴 栾洁 |
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| 作者单位： | 张瑾 (江苏省无锡药品检验所,无锡,214021)； 丁晴 (江苏省无锡药品检验所,无锡,214021)； 栾洁 (江苏省无锡药品检验所,无锡,214021)； |
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| 摘 要： | 目的建立了金银花露中6种防腐剂的含量测定方法。方法采用HPLC法。以0．025mol·L-1磷酸二氢钠溶液（磷酸调pH3．7）．甲醇为流动相梯度洗脱，分别在波长228nm、258nm处测定6种防腐剂的含量。结果9个生产厂家的19批金银花露中，有7个生产厂家的16批样品检出苯甲酸，山梨酸，对羟基苯甲酸乙酯的一种或两种。2个生产厂家的3批样品未检测出上述6种防腐剂。结论该方法简便、准确、重现性好，可用于中药液体制剂中常见防腐剂的含量测定。
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| 关 键 词： | HPLC 金银花露 防腐剂 |
Determination of six types of preservatives in Distilled liquid of honeysuck- le by HPLC |
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| ZHANG Jin,DING Qin,LUAN Jie.Determination of six types of preservatives in Distilled liquid of honeysuck- le by HPLC[J].Strait Pharmaceutical Journal,2013,25(9):80-82. |
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| Authors: | ZHANG Jin DING Qin LUAN Jie |
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| Institution: | (Jiangsu Wuxi Drug verification, Wuxi 214021, China) |
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| Abstract: | OBJECTIVE To establish a method to determine six types of preservatives in distilled liquid of hon- eysuckle. METHODS Using HPLC with the gradient elution of 0. 025mol ~ L-1 Phosphoric acid sodium solution to the hydrogen （ Phosphoric acid. key ph3 ） - Methyl alcohol detected the content of Six types of preservatives at 228nm or 258nm. RESULTS One or two of benzoic acid, sorbic acid and ethyl p-hydroxybenzoate were determined in 16 samples from 7 pharmaceutical factories, and none in 3 samples from the other two pharmaceutical facto- ries. CONCLUSION The method is simple, accurate and repeatable for determination of the common preservatives in Liquid herbal medicine. |
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| Keywords: | HPLC Distilled liquid of honeysuckle Preservatives |
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