SD大鼠牙周炎动物模型的建立

目的：利用SD大鼠建立一种近似人类临床牙周炎的牙周炎动物模型。方法：将12月龄SD大鼠36只随机分为3组：①正常对照组（N组）；②高糖饮食＋结扎＋牙龈剥离（P1组）；③牙龈剥离＋高糖饮食＋结扎＋牙龈卟啉单胞菌（P2组）。结果：组织学结果显示P，组4周时可见牙周炎表现，个体差异大；8周时形成深牙周袋，牙槽骨吸收，个体差异小；P2组4周时可见明显牙周炎症状，个体差异小。结论：以本法建立的牙周炎动物模型，能模拟临床牙周炎自然发生的过程，用于牙周炎的进一步研究。

Establishment of experimental animal model of periodontitis in SD rats

AIM: To establish experimental periodontitis animal model in SD rats.METHODS: Thirty six SD rats(12 months of age) were randomly divided into a control group(N) and two experimental groups(P_1 and P_2).In two experimental groups steel-wire ligatures were given to the gingivas around the left first maxillary molars;the amimals were provided with high glucose food and drink.Additionaly,group P_2 was inoculated with P.gingivalis.RESULTS: At week 4,histological examination showed the manifestation of periodontitis in two experimetal groups,but there was more significant individual difference in group P_1 than in group P_2.At week 8,histological examination showed deep periodontal pockets and alveolar bone loss in two experimental groups.CONCLUSION: This method can simulate the natural periodontitis progress of patients.