中国人群肺癌发病危险因素的Meta分析

目的]探讨中国人群肺癌发生的主要危险因素,为预防决策提供依据。方法]利用Meta分析方法对我国1995～2007年间公开发表的有关肺癌危险因素病例对照研究的12篇文献资料进行定量综合分析。结果]各因素合并OR值及95%CI分别为:吸烟OR=2.7820(2.3428～3.3035);油烟OR=2.6257(1.7312～3.9879);家族肿瘤史OR=1.8075(1.4745～2.2157);肺结核OR=2.6018(1.8946～3.5731);慢性支气管炎OR=2.3052(1.8013～2.9500);精神因素OR=2.2648(1.8364～2.7932);饮酒OR=1.4942(1.2491～1.7873);被动吸烟OR=1.7064(0.9109～3.1965);新鲜蔬菜OR=0.5376(0.4445～0.6503)。结论]吸烟、饮酒、油烟、家族肿瘤史、肺结核、慢性支气管炎、精神因素是目前中国人群肺癌发病的危险因素;而多吃新鲜蔬菜是肺癌发生的保护性因素。

META-ANALYSIS OF THE RISK FACTOR OF LUNG CANCER AMONG CHINESE PEOPLE

Objective] To explore the main risk factors related to the incidence of lung cancer among Chinese people so as to provide basis for decision making on lung cancer prevention. Methods] 12 published literatures of case-control studies on risk factor of lung cancer from 1995 to 2007 were collected and analyzed synthetically by Meta-analysis. Results] The pooled odds radio values and 95%CI were:smoking OR=2.7820(2.3428-3.3035) ;cooking smoking OR=2.6257(1.7312-3.9879) ;Family history of tumor OR =1.8075( 1.4745-2.2157) ;pulmonary tuberculosis OR =2.6018( 1.8946-3.5731) ;chronic bronchitis OR=2.3052(1.8013-2.9500) ;mentality OR=202648(1.8346-2.7932) ) ;alcohol drinking OR=1.4942(1.2491-1.7873) ;exposure to environmental tobacco smoking OR=1.7064(0.9109-3.1965) ;and fresh vegetables OR=0.5376(0.4445-0.6503) . Conclusion] The risk factors influencing the incidence of lung cancer in Chinese people were smoking,alcohol drinking,cooking smoking,family history of tumor,pulmonary tuberculosis,chronic bronchitis,mentality and so on,while fresh vegetables were the protectoral factors.