E-Cadherin在胃癌中的表达及意义

目的　探讨上皮型钙粘蛋白 (E -Cadherin ,E -Cad)的表达与胃癌的分化、浸润、淋巴结转移的关系。方法　采用免疫组化S -P法和抗E -Cad抗体对 65例胃癌及正常胃粘膜上皮组织E -Cadherin表达进行研究。结果　早期胃癌及进展期胃癌组织中E -Cadherin表达阳性率分别为 85 7%、5 0 0 % ,正常胃粘膜上皮全部表达 ,E -Cadherin的表达与癌组织分化程度及淋巴结转移密切相关 (P <0 0 1) ,与浸润深度相关 (P <0 0 5 )。结论　上皮型钙粘蛋白表达对评估胃癌的浸润、转移具有重要意义 ,检测E -Cadherin可以作为判断胃癌预后的指标

Expression of E - Cadherin and Its Significance in Gastric Carcinoma

Objective To investigate the relationship of expression of E-Cadherin with differentiation,infiltration and node metastasis in gastric carcinoma.Methods 65 cases of gastric carcinoma and adjacent normal stomach mucomembrnous epithelium were examined for E-Cadherin by S-P immumnohistochemistry of anti-E-Cadherin monoclonal antibody.Results The positive rate of E-Cadherin in early gastric cancer of all histological types was 85.7%,positive rate of E-Cadherin in advanced gastric cancer was 50%,while E-Cadherin expression was observed in all normal stomach mucous epithelium.E-Cadherin expression was associated with carcinoma differentiation,lymph node metastasis ( P <0.01),and invasive depth( P <0.05).Conclusions E-Cadherin expression,as a clinical valuable marker, has a great significance in assessing lymph node metastasis and survival.