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| 玉郎伞提取物对大鼠心肌缺血再灌注损伤的保护作用 | |
| 引用本文： | 焦杨,段小群,孔晓龙,蒋伟哲,黄仁彬. 玉郎伞提取物对大鼠心肌缺血再灌注损伤的保护作用[J]. 中国医院药学杂志, 2004, 24(12): 726-727 |
| 作者姓名： | 焦杨 段小群 孔晓龙 蒋伟哲 黄仁彬 |
| 作者单位： | 1. 广西医科大学药理学教研室,广西,南宁,530021 2. 广西医科大学第一附属医院,广西,南宁,530021 |
| 摘 要： | 目的:研究玉郎伞(YLS)对心肌缺血再灌注损伤(MIRI)的影响.方法:以Wistar大鼠制备MIRI模型(结扎冠状动脉5 min后再灌注30 min),观察YLS对心肌梗死面积及心肌组织丙二醛(MDA)含量、超氧化物歧化酶(SOD)活力及血清中乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)活性生化指标的影响.结果:YLS明显降低心肌梗死范围、提高心肌组织中SOD活力、降低其MDA含量,同时降低血清中CK和LDH活力(P<0.01或P<0.05).结论:YLS对大鼠心肌缺血再灌注损伤具有显著的保护作用. |
| 关 键 词： | 玉郎伞 心肌缺血再灌注损伤 心肌梗死面积 超氧化物歧化酶 乳酸脱氢酶 |
| 文章编号： | 1001-5213(2004)12-0726-02 |
| 修稿时间： | 2004-03-15 |
Protective effect of Yulangsan extractive on myocardial ischemia reperfusion injury in rats |
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| JIAO Yang ,DUAN Xiao qun ,KONG Xiao long ,JIANG Wei zhe ,HUANG Ren bin. Protective effect of Yulangsan extractive on myocardial ischemia reperfusion injury in rats[J]. Chinese Journal of Hospital Pharmacy, 2004, 24(12): 726-727 | |
| Authors: | JIAO Yang DUAN Xiao qun KONG Xiao long JIANG Wei zhe HUANG Ren bin |
| Affiliation: | JIAO Yang 1,DUAN Xiao qun 1,KONG Xiao long 2,JIANG Wei zhe 2,HUANG Ren bin 1 |
| Abstract: | OBJECTIVE To study the effect of YLS on myocardial ischemia reperfusion injury in rats.METHODS An experimental MIRI (Coronary artery ligation for 5 min followed by reperfusion for 30 min .) in wistar rats were used for the determination of the area of myocardial ischemia,the activities of superoxide dismutase (SOD),lactate dehydrogenase (LDH) and creatine kinase (CK),and the content of MDA in myocardium or serum following the pretreatment with YLS.RESULTS YLS could significantly decrease the content of MDA and the activity of CK and markedly reduce the area of myocardial ischemia and increase the activity of SOD ( P < 0.01 or P < 0.05 ).CONCLUSION YLS has a significant protective effect on myocardial ischemia reperfusion injury in rats. |
| Keywords: | Yulangsan myocardial ischemia reperfusion injury myocardial ischemia area superoxide dismutase lactate dehydrogenase |
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