还原型谷胱甘肽对2型糖尿病患者氧化应激水平的影响

目的观察还原型谷胱甘肽对2型糖尿病以及伴有尿白蛋白排泄率（UAER）升高患者氧化应激水平的影响。方法选择62例2型糖尿病患者，根据UAER是否升高分为两组，单纯糖尿病组（DM组）30例，糖尿病合并UAER升高组（DM2组）32例，所有患者在降糖治疗的基础上，给予还原型谷胱甘肽治疗。观察还原型谷胱甘肽治疗前后患者空腹血糖（FPG）、总胆固醇（Tc）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、肌酐（Cr）、血尿素氮（BUN）、UAER、丙二醛（MDA）、超氧化物歧化酶（SOD）等水平的变化，并与同期健康体检者25例（对照组）比较。结果三组治疗前TG、HDL-C、LDL-C水平比较差异无统计学意义（P〉0．05），DM2组治疗前TC较对照组、DM组有明显升高，差异有统计学意义（P〈0．05）；DM组和DM2组治疗后TC、LDL-C均较治疗前有明显降低，差异有统计学意义（P〈0．05），TG有下降趋势，而HDL-C有升高趋势，但差异无统计学意义（P〉0．05）。与对照组比较，DM组和DM2组治疗前血清SOD水平明显下降，而MDA水平明显升高，差异有统计学意义（P〈0．05）；与DM组比较，DM2组治疗前血清SOD水平进一步下降，而MDA水平进一步升高，差异有统计学意义（P〈0．05）；DM组和DM2组治疗后血清SOD水平有所升高，而MDA水平有所下降，与治疗前比较差异有统计学意义（P〈0．05）。DM组和DM2组治疗后UAER水平均较治疗前有不同程度的降低，差异有统计学意义（P〈0．05）。以SOD、MDA为应变量，UAER为自变量，经相关分析发现SOD与UAER呈负相关（r=一0．64，P〈0．05），而MDA与UAER呈正相关（r=0．56，P〈0．05）。在校正年龄、TC、TG、HDL-C、LDL-C、FPG等因素的影响后，SOD与UAER仍呈负相关（r=一0．41，P〈0．05），而MDA与UAER仍呈正相关（r=0．37，P〈0．05）。结?

Effect of reduced glutathione on the oxidative stress in type 2 diabetes mellitus

Objective To observe the effect of reduced glutathione on the oxidative stress in type 2 diabetes mellitus with high urinary albumin excretion rate（UAER）. Methods Sixty-two patients with type 2 diabetes mellitus were divided into diabetes group（ DM group, 30 cases） and high UAER group（ DM2 group, 32 cases）. All of the patients were given reduced glutathione on the basis of glucose-lowering treatment. The changes of fasting plasma glucose （ FPG ）, total cholestrol （TC）, triaeylglycerol （ TG ）, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）,creatinine （Cr）, blood urea nitrogen （BUN） ,UAER,malondialdehyde （MDA）, superoxide dismutase （SOD） before and after trearnent was collected and compared with that of 25 healthy subjects （control group）. Results There was no significant difference in TG, HDL-C, LDL-C before treatment among three groups （P 〉 0.05 ）. TC before treatment in DM2 group was higher than that in control group and DM group,and there was significant difference （P 〈 0.05 ）. TC, LDL-C after treatment in DM group and DM2 group was decreased compared with that before treatment, and there was significant difference （P 〈 0.05 ）, TG had a downward tendency, HDL-C had a rising trend,but there was no significant difference （P 〉 0.05 ）. Compared with that in control group,SOD in DM group and DM2 group was decreased before treatment,and MDA was increased,and there was significant difference （P 〈 0.05 ）. Compared with that in DM group, SOD was decreased before treatment, and MDA was increased, and there was significant difference （P 〈 0.05 ）. SOD after treatment was higher than that before treatment and MDA after treatment was lower than that before treatment in DM group and DM2 group, and there was significant difference （P 〈 0.05 ）. UAER was decreased after treatment compared with that before treatment in DM group and DM2 group, and there was significant difference （P 〈 0.05 ?